التفاصيل البيبلوغرافية
| العنوان: |
Influence of acute hypoxia and radiation quality on cell survival |
| المؤلفون: |
Cläre von Neubeck, Wilma Kraft-Weyrather, Marco Durante, Corinna Schicker, Walter Tinganelli, Ning-Yi Ma, Andreas Maier |
| المساهمون: |
Tinganelli, W., Ma, N. -Y., Von Neubeck, C., Maier, A., Schicker, C., Kraft-Weyrather, W., Durante, M. |
| المصدر: |
Journal of Radiation Research |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Male, Cell Survival, Health, Toxicology and Mutagenesis, Medizin, Linear energy transfer, chemistry.chemical_element, CHO Cells, Biology, Oxygen, 030218 nuclear medicine & medical imaging, Andrology, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Cell Line, Tumor, Cricetinae, Relative biological effectiveness, Radiobiology and Clinics, Animals, Humans, Linear Energy Transfer, Radiology, Nuclear Medicine and imaging, Irradiation, Radiosensitivity, Ions, Radiation, Radiotherapy, business.industry, hypoxia, X-Rays, Prostatic Neoplasms, Dose-Response Relationship, Radiation, Oxygenation, Fibroblasts, Cell Hypoxia, Rats, 3. Good health, chemistry, radiosensitivity, 030220 oncology & carcinogenesis, Cancer cell, LET, Oxygen enhancement ratio, OER, Nuclear medicine, business |
| الوصف: |
To measure the effect of acute oxygen depletion on cell survival for different types of radiation, experiments have been performed using Chinese hamster ovary (CHO) cells and RAT-1 rat prostate cancer cells. A special chamber has been developed to perform irradiations under different levels of oxygenation. The oxygen concentrations used were normoxia (air), hypoxia (94.5% N₂, 5% CO₂, 0.5% O₂) and anoxia (95% N ₂, 5% CO₂). Cells were exposed to X-rays and to C-, N- or O-ions with linear energy transfer (LET) values ranging from 100-160 keV/μm. The oxygen enhancement ratio (OER) and relative biological effectiveness (RBE) values have been calculated from the measured clonogenic survival curves. For both cell lines, the X-ray OER depended on the survival level. For particle irradiation, OER was not dependent on the survival level but decreased with increasing LET. The RBE of CHO cells under oxic conditions reached a plateau for LET values above 100 keV/μm, while it was still increasing under anoxia. In conclusion, the results demonstrated that our chamber could be used to measure radiosensitivity under intermediate hypoxia. Measurements suggest that ions heavier than carbon could be of additional advantage in the irradiation, especially of radioresistant hypoxic tumor regions. © 2013 The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1bfad33696a44210a162a87577362b
http://hdl.handle.net/11588/857580 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....4f1bfad33696a44210a162a87577362b |
| قاعدة البيانات: |
OpenAIRE |
