Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
| العنوان: | Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications |
|---|---|
| المؤلفون: | Marina Soković, Ana S. Ribeiro, Diana Ferreira, Raúl Fangueiro, Dejan Stojković, Isabel C.F.R. Ferreira, Ricardo C. Calhelha, Sofia M. Costa, Lillian Barros |
| المساهمون: | Universidade do Minho |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Materials science, Polymers and Plastics, Biocompatibility, General Chemical Engineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Nanocellulose, Chitosan, chemistry.chemical_compound, Materials Chemistry, Environmental Chemistry, Science & Technology, Electrospun nanofibers, Ethylene oxide, technology, industry, and agriculture, General Chemistry, 021001 nanoscience & nanotechnology, Cellulose nanocrystals (CNC), Electrospinning, 0104 chemical sciences, Drug delivery systems, Membrane, chemistry, Chemical engineering, Nanofiber, Drug delivery, Acacia natural extract, 0210 nano-technology |
| الوصف: | The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications. The authors are thankful to TSSiPRO project, operation code NORTE01-0145-FEDER-000015. The authors are also grateful to FCT, Portugal for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to 2C2T (UID/CTM/00264/2019). D. P. Ferreira thank the national funding by FCT through the individual scientific employment program-contract (CEECIND/02803/2017), S. M. Costa thank the FCT PhD Scholarship (SFRH/BD/147517/2019), and L. Barros and R. Calhelha thank the institutional scientific employment program-contract. This work has been supported by the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1c144b69059ed8a3f3725e0276e308 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4f1c144b69059ed8a3f3725e0276e308 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |