Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission
| العنوان: | Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission |
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| المؤلفون: | Xiao-jie Chen, Qi-xiao Cui, Guo-li Wang, Xiao-li Li, Xiao-lin Zhou, Hui-jie Zhao, Ming-qian Zhang, Min-jing Li, Xiao-juan He, Qiu-sheng Zheng, Yu-liang Wang, Defang Li, Pan Hong |
| المصدر: | Journal of Natural Products. 85:2351-2362 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Carcinogenesis, Organic Chemistry, Mice, Nude, Pharmaceutical Science, Apoptosis, Mitochondrial Dynamics, Analytical Chemistry, Mice, Complementary and alternative medicine, Stomach Neoplasms, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Medicine, Protein Kinases, Cell Proliferation |
| الوصف: | Sanggenon C is a flavonoid extracted from the root bark of white mulberry, which is a traditional Chinese medicine with anti-inflammatory, antioxidative, and antitumor pharmacological effects. In this study, sanggenon C was found to inhibit human gastric cancer (GC) cell proliferation and colony formation, induce GC cell cycle arrest in the G0-G1 phase, and promote GC cell apoptosis. Moreover, sanggenon C was found to decrease the level of mitochondrial membrane potential in GC cells and inhibit mitochondrial fission. Mechanistically, RNA sequencing, bioinformatics analysis, and a series of functional analyses confirmed that sanggenon C inhibited mitochondrial fission to induce apoptosis by blocking the extracellular regulated protein kinases (ERK) signaling pathway, and constitutive activation of ERK significantly abrogated these effects. Finally, sanggenon C was found to suppress the growth of tumor xenografts in nude mice without obvious side effects to the vital organs of animals. This study reveals that sanggenon C could be a novel therapeutic strategy for GC treatment. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f258eaaf6849f7ccd9191027a950ec1 https://doi.org/10.1021/acs.jnatprod.2c00524 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4f258eaaf6849f7ccd9191027a950ec1 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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