Effective Treatment of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus Species Infections in Macrophages, Biofilm, and Mice by Using Liposomal Ciprofloxacin
| العنوان: | Effective Treatment of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus Species Infections in Macrophages, Biofilm, and Mice by Using Liposomal Ciprofloxacin |
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| المؤلفون: | Luiz E. Bermudez, Valerie Elias, James Blanchard, David Cipolla, Igor Gonda |
| المصدر: | Antimicrobial Agents and Chemotherapy. 62 |
| بيانات النشر: | American Society for Microbiology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbial Sensitivity Tests, Mycobacterium abscessus, Polyethylene Glycols, Microbiology, Mice, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Experimental Therapeutics, Pharmacology (medical), Pharmacology, Lung, biology, business.industry, Macrophages, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, In vitro, Mice, Inbred C57BL, Ciprofloxacin, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Biofilms, Liposomes, Female, Nontuberculous mycobacteria, Nasal administration, business, Mycobacterium avium, Mycobacterium, medicine.drug |
| الوصف: | Nontuberculous mycobacteria (NTM) affect an increasing number of individuals worldwide. Infection with these organisms is more common in patients with chronic lung conditions, and treatment is challenging. Quinolones, such as ciprofloxacin, have been used to treat patients, but the results have not been encouraging. In this report, we evaluate novel formulations of liposome-encapsulated ciprofloxacin (liposomal ciprofloxacin) in vitro and in vivo. Its efficacy against Mycobacterium avium and Mycobacterium abscessus was examined in macrophages, in biofilms, and in vivo using intranasal instillation mouse models. Liposomal ciprofloxacin was significantly more active than free ciprofloxacin against both pathogens in macrophages and biofilms. When evaluated in vivo, treatment with the liposomal ciprofloxacin formulations was associated with significant decreases in the bacterial loads in the lungs of animals infected with M. avium and M. abscessus. In summary, topical delivery of liposomal ciprofloxacin in the lung at concentrations greater than those achieved in the serum can be effective in the treatment of NTM, and further evaluation is warranted. |
| تدمد: | 1098-6596 0066-4804 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f40ba98a343da412248f7870bb21fbd https://doi.org/10.1128/aac.00440-18 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4f40ba98a343da412248f7870bb21fbd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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