Population Pharmacokinetics and Bayesian Estimation of the Area Under the Concentration‐Time Curve for Ganciclovir in Adult Chinese Renal Allograft Recipients After Valganciclovir Administration
| العنوان: | Population Pharmacokinetics and Bayesian Estimation of the Area Under the Concentration‐Time Curve for Ganciclovir in Adult Chinese Renal Allograft Recipients After Valganciclovir Administration |
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| المؤلفون: | Wen-Bin Rui, Xi-Han Wang, Kun Shao, Jia-Qian Lu, Pei-jun Zhou, Shan-Shan Hu, Bing Chen, Hui-Min An, Xiao-Hui Zhai |
| المصدر: | The Journal of Clinical Pharmacology. 61:328-338 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Ganciclovir, medicine.medical_specialty, Adolescent, viruses, Population, Urology, Antiviral Agents, Models, Biological, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Asian People, Pharmacokinetics, medicine, Humans, Valganciclovir, Pharmacology (medical), education, Pharmacology, education.field_of_study, Creatinine, Dose-Response Relationship, Drug, business.industry, Bayes Theorem, Middle Aged, Prodrug, Kidney Transplantation, Nonlinear Dynamics, chemistry, Area Under Curve, 030220 oncology & carcinogenesis, Renal allograft, Female, Time curve, business, medicine.drug |
| الوصف: | Valganciclovir (VGCV) is the prodrug of ganciclovir (GCV). The objective of this study was to establish a population pharmacokinetic model (PPK) of GCV to investigate the PK characteristics of GCV after administration of VGCV in adult Chinese renal allograft recipients. Seventy Chinese renal allograft recipients were given 450 mg (n = 41) or 900 mg (n = 29) VGCV daily. Blood samples were drawn 0-24 hours after 5 days' therapy, and GCV plasma levels were determined. The PPK model was constructed using nonlinear mixed-effects modeling, and the Bayesian estimation of AUC0-24h was constructed for an individual patient based on limited plasma samples. The PK of GCV was best described by a 2-compartment model with a first-order absorption process. The CL/F, V2 /F, Q/F, V3 /F, Ka , and lag time of GCV were 15.8 ± 0.71 L/h, 10.9 ± 2.38 L, 3.98 ± 0.40 L/h, 167 ± 44.0 L, 0.23 ± 0.0078 1/h, and 0.93 ± 0.017 hours, respectively. Clearance of creatinine was found to have a significant impact on the CL/F of GCV (P < .01). Sampling strategies consisted of plasma concentrations 0 and 2 and 0, 2, and 4 hours after VGCV administration were shown to be suitable for the estimation of the GCV AUC0-24h . The PPK model was acceptable and can describe the PK of GCV in Chinese renal transplant patients administered VGCV. The AUC0-24h of GCV in Chinese renal transplant patients can be calculated by a limited sampling strategy method. |
| تدمد: | 1552-4604 0091-2700 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ed551f6a4c49cd4d97615be957d9c https://doi.org/10.1002/jcph.1735 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....505ed551f6a4c49cd4d97615be957d9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524604 00912700 |
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