SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
| العنوان: | SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans |
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| المؤلفون: | Philip A. Mudd, Anastasia A. Minervina, Mikhail V. Pogorelyy, Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J. Schmitz, Tingting Lei, Alem Haile, Allison M. Kirk, Robert C. Mettelman, Jeremy Chase Crawford, Thi H.O. Nguyen, Louise C. Rowntree, Elisa Rosati, Katherine A. Richards, Andrea J. Sant, Michael K. Klebert, Teresa Suessen, William D. Middleton, Joshua Wolf, Sharlene A. Teefey, Jane A. O’Halloran, Rachel M. Presti, Katherine Kedzierska, Jamie Rossjohn, Paul G. Thomas, Ali H. Ellebedy, Jeremie H. Estepp, Stacey Schultz-Cherry, Maureen A. McGargill, Aditya Gaur, James Hoffman, Motomi Mori, Li Tang, Elaine Tuomanen, Richard Webby, Randall T. Hayden, Hana Hakim, Diego R. Hijano, Kim J. Allison, E. Kaitlynn Allen, Resha Bajracharya, Walid Awad, Lee-Ann Van de Velde, Brandi L. Clark, Taylor L. Wilson, Aisha Souquette, Ashley Castellaw, Ronald H. Dallas, Ashleigh Gowen, Thomas P. Fabrizio, Chun-Yang Lin, David C. Brice, Sean Cherry, Ericka Kirkpatrick Roubidoux, Valerie Cortez, Pamela Freiden, Nicholas Wohlgemuth, Kendall Whitt |
| المصدر: | Cell |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, T Follicular Helper Cells, Receptors, Antigen, T-Cell, Article, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, Jurkat Cells, CD4+ T cell, Humans, T follicular helper cell, BNT162 Vaccine, HLA-DP beta-Chains, B-Lymphocytes, Vaccines, Synthetic, Immunodominant Epitopes, SARS-CoV-2, Vaccination, mRNA vaccination, Immunity, COVID-19, Middle Aged, lymph node, Germinal Center, Clone Cells, Cytokines, Female, Lymph Nodes, mRNA Vaccines, Protein Multimerization, Peptides |
| الوصف: | SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (TFH) cell responses contribute to this outstanding immunogenicity. Using fine needle aspiration of draining axillary lymph nodes from individuals who received the BNT162b2 mRNA vaccine, we evaluated the T cell receptor sequences and phenotype of lymph node TFH. Mining of the responding TFH T cell receptor repertoire revealed a strikingly immunodominant HLA-DPB1∗04-restricted response to S167-180 in individuals with this allele, which is among the most common HLA alleles in humans. Paired blood and lymph node specimens show that while circulating S-specific TFH cells peak one week after the second immunization, S-specific TFH persist at nearly constant frequencies for at least six months. Collectively, our results underscore the key role that robust TFH cell responses play in establishing long-term immunity by this efficacious human vaccine. Analysis of draining lymph nodes of individuals vaccinated BNT162b2 mRNA vaccine against SARS-CoV-2 identifies viral spike-specific follicular helper CD4+ T cells that persist for months and contribute to long-term immunity. |
| تدمد: | 0092-8674 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507c5f3fbde1e07b6191137f41275e38 https://doi.org/10.1016/j.cell.2021.12.026 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....507c5f3fbde1e07b6191137f41275e38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00928674 |
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