Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice
| العنوان: | Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice |
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| المؤلفون: | Satoko Hattori, Hirotaka Shoji, Nao Hirata, Hiroshi Funakoshi, Tsuyoshi Miyakawa |
| المصدر: | Neuropsychopharmacology Reports |
| بيانات النشر: | John Wiley and Sons Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Kynurenine pathway, Inflammation, Biology, Anxiety, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, medicine, Animals, Indoleamine-Pyrrole 2,3,-Dioxygenase, Pharmacology (medical), Indoleamine 2,3-dioxygenase, Maze Learning, Social Behavior, comprehensive behavioral test battery, Pharmacology, chemistry.chemical_classification, Working memory, Original Articles, Phenotype, Mice, Inbred C57BL, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Enzyme, Endocrinology, indoleamine 2,3‐dioxygenase, chemistry, Knockout mouse, Original Article, medicine.symptom, 030217 neurology & neurosurgery, Kynurenine, Gene Deletion, Locomotion, kynurenine pathway |
| الوصف: | Aim Indoleamine 2,3‐dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP). IDO1 is an initial rate‐limiting enzyme in the KP and is activated by stress and/or inflammation. The perturbation of IDO1 activity, which causes KP imbalance, is associated with psychiatric and neurological disorders. It has been reported that wild‐type (WT) mice under inflammatory conditions show increased anxiety‐like behavior and decreased novel object recognition, whereas Ido1 knockout (KO) mice do not display these behaviors. However, the behavioral phenotypes of Ido1 KO mice have not yet been fully examined under non‐inflammatory conditions. Methods We subjected Ido1 KO mice to a comprehensive behavioral test battery under normal conditions. Results Ido1 KO mice and WT mice showed similar locomotor activity, anxiety‐like behavior, social behavior, depression‐like behavior, and fear memory. In the T‐maze test, Ido1 KO mice exhibited weak but nominally significant impairment in the working memory task of the T‐maze, but this result failed to reach study‐wide significance. Conclusions Ido1 KO mice did not show any clear behavioral abnormalities under normal conditions. Further studies may be necessary to investigate their behavioral phenotype under inflammatory conditions due to their known roles in inflammation. It has been reported that wild‐type (WT) mice under inflammatory conditions show increased anxiety‐like behavior and decreased novel object recognition, whereas Ido1 knockout (KO) mice do not display these behaviors. However, the behavioral phenotypes of Ido1 KO mice have not yet been fully examined under non‐inflammatory conditions. Here, we subjected Ido1 KO mice to a comprehensive behavioral test battery under normal conditions. |
| اللغة: | English |
| تدمد: | 2574-173X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50efcb1c3cb80065fb6dedf5801de619 http://europepmc.org/articles/PMC7292290 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....50efcb1c3cb80065fb6dedf5801de619 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2574173X |
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