Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver
| العنوان: | Zfat Is Indispensable for the Development of Erythroid Cells in the Fetal Liver |
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| المؤلفون: | Shiori Yamano, Shuhei Ishikura, Toshiyuki Tsunoda, Senji Shirasawa, Midori Koyanagi, Aya Fujikane, Kensuke Nishi, Keiko Doi, Yoko Tanaka |
| المصدر: | Anticancer Research. 39:4495-4502 |
| بيانات النشر: | Anticancer Research USA Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, Anemia, T-Lymphocytes, T cell, Apoptosis, Transferrin receptor, Biology, Fetal Development, Mice, 03 medical and health sciences, Fetus, 0302 clinical medicine, Erythroid Cells, Antigens, CD, Receptors, Transferrin, medicine, Animals, Humans, Erythropoiesis, Gene knockdown, Thyroiditis, Autoimmune, Gene Expression Regulation, Developmental, Cell Differentiation, General Medicine, medicine.disease, medicine.anatomical_structure, Liver, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, embryonic structures, Cancer research, Ex vivo, Transcription Factors |
| الوصف: | Background/aim In mice, fetal liver is the first tissue of definitive erythropoiesis for definitive erythroid expansion and maturation. ZFAT, originally identified as a candidate susceptibility gene for autoimmune thyroid disease, has been reported to be involved in primitive hematopoiesis and T cell development. The aim of this study was to examine whether or not Zfat is involved in definitive erythropoiesis in the fetal liver during mammalian development. Materials and methods The role of Zfat during mouse fetal erythropoiesis in the fetal liver was examined using tamoxifen-inducible CreERT2 Zfat-deficient mice. Results Zfat-deficient mice exhibit moderate anemia with small and pale fetal liver through a decreased number of erythroblasts by E12.5. Apoptosis sensitivity in fetal liver erythroid progenitors was enhanced by Zfat-deficiency ex vivo. Moreover, Zfat knockdown partially inhibited CD71-/lowTer119- to CD71highTer119- transition of fetal liver erythroid progenitors with impairment in the elevation of CD71 expression. Conclusion Zfat plays a critical role for erythropoiesis in the fetal liver. |
| تدمد: | 1791-7530 0250-7005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510f5fe9f13a115f43b83c8b20889ed4 https://doi.org/10.21873/anticanres.13625 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....510f5fe9f13a115f43b83c8b20889ed4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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