Additional file 4. Supplementary Figure 2: DNA methylation at the X inactivation center in female and male E2.75 wt embryos and Smchd1matΔ embryos. Histogram tracks show methylation in single embryos at individual CpG sites (0–100%, 4 wild-type and 4 matΔembryos shown for each sex). Note that coverage in single-embryo whole-genome bisulfite sequencing is sparse, only 0–2X. The aggregate line plots show the average methylation per genotype across 10 kb windows (sliding by 5 kb, 0–100%). Females: n=6 wt and 4 matΔ; males: n=5 wt and 8 matΔ.
