High-Dose Mefloquine in the Treatment of Multidrug-Resistant Falciparum Malaria
| العنوان: | High-Dose Mefloquine in the Treatment of Multidrug-Resistant Falciparum Malaria |
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| المؤلفون: | M. Thieren, H. K. Webster, François Nosten, L Phaipun, Tan Chongsuphajaisiddhi, F O ter Kuile, Michael D. Edstein, Christine Luxemburger, Nicholas J. White |
| المساهمون: | Other departments |
| المصدر: | Journal of infectious diseases, 166(6), 1393-1400. Oxford University Press Scopus-Elsevier Europe PubMed Central |
| بيانات النشر: | Oxford University Press (OUP), 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Nausea, medicine.medical_treatment, Plasmodium falciparum, Drug Resistance, Drug resistance, Gastroenterology, Sex Factors, Recurrence, Internal medicine, medicine, Animals, Humans, Immunology and Allergy, Malaria, Falciparum, Child, Probability, Chemotherapy, Mefloquine, business.industry, Incidence (epidemiology), Infant, medicine.disease, Regimen, Treatment Outcome, Infectious Diseases, Child, Preschool, Anesthesia, Acute Disease, Vomiting, Female, medicine.symptom, business, Malaria, Follow-Up Studies, medicine.drug |
| الوصف: | The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. The clinical and parasitologic responses were significantly more rapid with M25. The incidence of treatment failures by day 7-9 was 7% for M15 and 1% for M25 (P = .03) and had increased to 40% and 9%, respectively, by day 28 (P < .0001). Overall failure rates were highest in children (P = .02). Parasite clearance times were a good predictor of the therapeutic response; all patients with parasitemia persisting > 5 days after treatment experienced subsequent recrudescence. Side effects were dose-related and included dizziness, anorexia, nausea, vomiting, and fatigue. Although vomiting < 1 h after treatment was more likely in young children, children overall tolerated mefloquine better than adults, and men better than women. The optimum treatment dose of mefloquine in this area is 25 mg/kg. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513d061200fe29131e091fab3bb80d60 https://doi.org/10.1093/infdis/166.6.1393 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....513d061200fe29131e091fab3bb80d60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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