Cerebral malaria: insight into pathology from optical coherence tomography
| العنوان: | Cerebral malaria: insight into pathology from optical coherence tomography |
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| المؤلفون: | Karl B. Seydel, Terrie E. Taylor, Chatonda Manda, Valentina Barrera, Simon P. Harding, Zhanhan Tu, Frank A Proudlock, Irene Gottlob, Viral Sheth, Jack Gormley, Nicholas A. V. Beare |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, genetic structures, Science, Malaria, Cerebral, Aftercare, Diagnostic Techniques, Ophthalmological, Paediatric research, Article, Retina, Ophthalmoscopy, chemistry.chemical_compound, Retinal Diseases, Medicine, Humans, Fluorescein Angiography, Malaria, Falciparum, Hypoxia, Child, Retinal thinning, Cerebral atrophy, Multidisciplinary, medicine.diagnostic_test, business.industry, Fundus photography, Infant, Retinal Vessels, Retinal, Fluorescein angiography, medicine.disease, eye diseases, Malaria, Cotton wool spots, medicine.anatomical_structure, chemistry, Child, Preschool, Female, sense organs, medicine.symptom, business, Tomography, Optical Coherence |
| الوصف: | PurposeWe aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to investigate its diagnostic potential.MethodsChildren with MR (n=43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, one month (n=31) and one year (n=8) post-discharge. Controls were comatose patients without malaria (n=6) and age/sex-matched healthy children (n=43). OCT changes and retinal layer thicknesses were compared.ResultsOn HH-OCT, hyper-reflective areas (HRAs) were seen in the inner retina of 81% of MR patients, corresponding to ischaemic retinal whiteningon fundus photography. Cotton wool spots were present in 37% and abnormal hyper-reflective dots, co-localized to capillary plexus, in 93%. Hyper-reflective vessel walls were present in 84%, and intra-retinal cysts in 9%. Vascular changes and cysts resolved within 48 hours. HRAs developed into retinal thinning at one month (p=0.027) whichwas more pronounced after one year (p=0.009).ConclusionsIschaemic retinal whitening is located within inner retinal layers, distinguishing it from cotton wool spots. Vascular hyper-reflectivity may represent the sequestration of parasitized erythrocytes in vessels, a key CM feature. The mechanisms of post-ischemic retinal atrophy and cerebral atrophy with cognitive impairment may be similar in CM survivors. HH-OCT has potential for monitoring patients, treatment response and predicting neurological deficits. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5155f1949031bcc80008b595f1cf0b1f http://europepmc.org/articles/PMC8333417 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5155f1949031bcc80008b595f1cf0b1f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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