Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014
| العنوان: | Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014 |
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| المؤلفون: | Masaki Yamamoto, Satoshi Nakano, Bin Chang, Makoto Ohnishi, Miki Nagao, Shigeru Suga, Takao Fujisawa, Satoshi Ichiyama, Yutaka Ito, Yasufumi Matsumura |
| المصدر: | Emerging Infectious Diseases, Vol 24, Iss 2, Pp 275-283 (2018) Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Serotype, Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014, Epidemiology, 030106 microbiology, Clone (cell biology), lcsh:Medicine, PCV13, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Serogroup, Meropenem, Pneumococcal conjugate vaccine, Pneumococcal Infections, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Antibiotic resistance, Japan, Streptococcus pneumoniae, Drug Resistance, Bacterial, medicine, polycyclic compounds, Humans, lcsh:RC109-216, meropenem resistance, antimicrobial resistance, bacteria, serotype 15A, ST63, Research, lcsh:R, PCV7, vaccines, medicine.disease, vaccination, Virology, Vaccination, pneumococcal conjugate vaccine, Pneumococcal infections, Infectious Diseases, medicine.drug |
| الوصف: | After the introduction of pneumococcal conjugate vaccines, the incidence of pneumococcal infections due to meropenem-resistant serotype 15A-ST63 strains increased in Japan. By using whole-genome sequencing and comparing sequences with those of clones from the United Kingdom, the United States, and Canada, we clarified the traits of the serotype 15A-ST63 clone. Our analysis revealed that the meropenem-resistant serotype 15A-ST63 strains from Japan originated from meropenem-susceptible strains from Japan. Recombination site prediction analysis showed that the meropenem-resistant strain-specific recombination regions included the pbp1a and pbp2b regions. A detailed analysis of the composition of these genes indicated that resistance seems to be caused by pbp1a recombination. The pbp1a gene in meropenem-resistant isolates was identical to that in multidrug (including meropenem)-resistant serotype 19A-ST320 pneumococci, which have spread in the United States. The global spread of pneumococci of this lineage is noteworthy because serotype 15A is not included in the currently used 13-valent pneumococcal conjugate vaccine. |
| اللغة: | English |
| تدمد: | 1080-6059 1080-6040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515c1469170b9ee62a3d8092f62458a1 https://wwwnc.cdc.gov/eid/article/24/2/17-1268_article |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....515c1469170b9ee62a3d8092f62458a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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