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Synthesis of 1-substituted phenazines as novel antichlamydial agents

التفاصيل البيبلوغرافية
العنوان:	Synthesis of 1-substituted phenazines as novel antichlamydial agents
المؤلفون:	Zhu Li, Yu Zhao, Ziyi Liu, Yi-Xin Zhu, Wen-Xia Xie, Xiaofeng Bao, He Jiang
المصدر:	Journal of Asian natural products research. 24(9)
سنة النشر:	2021
مصطلحات موضوعية:	Pharmacology, Molecular Structure, Chemistry, Organic Chemistry, Pharmaceutical Science, General Medicine, Combinatorial chemistry, Analytical Chemistry, Structure-Activity Relationship, Complementary and alternative medicine, Drug Discovery, Ic50 values, Molecular Medicine, Phenazines, Cytotoxicity, Trifluoromethanesulfonate, Palladium
الوصف:	A novel series of 1-substituted phenazines 4a-4l were designed and synthesized via Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC50 values from 1 to 10 μM. Among them, compounds 4c and 4i exhibited the best antichlamydial activity with IC50 values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.
تدمد:	1477-2213
URL الوصول:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51790b103bc458883d7bc08fda994679 https://pubmed.ncbi.nlm.nih.gov/34657526
رقم الأكسشن:	edsair.doi.dedup.....51790b103bc458883d7bc08fda994679
قاعدة البيانات:	OpenAIRE

الوصف
تدمد:	14772213