Validation of the LEFt score, a newly proposed diagnostic tool for deep vein thrombosis in pregnant women
| العنوان: | Validation of the LEFt score, a newly proposed diagnostic tool for deep vein thrombosis in pregnant women |
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| المؤلفون: | Emmanuelle Le Moigne, Grégoire Le Gal, Marc Philip Righini, Anne-Cecile Arnoult, Luc Bressollette, Jean-Luc Bosson, Julie Meunier, Céline Genty |
| المساهمون: | Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Santé Publique (CIC Grenoble - DSP), CHU de Grenoble , Centre Hospitalier Universitaire de Grenoble, France, Laboratoire Paragraphe (PARAGRAPHE), Université Paris 8 Vincennes-Saint-Denis (UP8)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Division of Vascular Medicine (DVM - GRENOBLE), CHU Grenoble, Service d'angiologie et d'hémostase (MR), Hôpital Universitaire de Genève, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Thrombosis Research Thrombosis Research, Elsevier, 2014, 134 (3), pp.664-7. ⟨10.1016/j.thromres.2014.07.009⟩ Thrombosis Research, Vol. 134, No 3 (2014) pp. 664-7 |
| بيانات النشر: | Elsevier BV, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Time Factors, Epidemiologic study, Future studies, [SDV]Life Sciences [q-bio], Deep vein, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Pregnancy, Deep vein thrombosis, Diagnosis, Prevalence, Edema, Prospective Studies, 030212 general & internal medicine, Ultrasonography, Doppler, Color, Ultrasonography, ddc:616, Venous Thrombosis, Obstetrics, Hematology, Thrombosis, 3. Good health, Europe, Pre- and post-test probability, medicine.anatomical_structure, Lower Extremity, Female, Radiology, Adult, medicine.medical_specialty, Pregnancy Complications, Cardiovascular, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Risk Assessment, Decision Support Techniques, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Predictive Value of Tests, medicine, Humans, cardiovascular diseases, business.industry, Reproducibility of Results, medicine.disease, Pregnancy Trimester, First, First trimester, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Introduction The diagnosis of deep vein thrombosis (DVT) in pregnant women remains a challenge for physicians. The ‘LEFt’ clinical decision rule was recently derived, that might help in estimating the pretest probability of DVT during pregnancy. Our aim was to externally validate the LEFt clinical decision rule among pregnant women included in the OPTIMEV study. Materials and Methods The OPTIMEV study is a diagnostic and epidemiologic study that included patients with suspected VTE between November 2004 and January 2006. All patients underwent standardized clinical data collection, and a bilateral whole-leg venous ultrasonography. A 3-month follow-up was performed in all patients with confirmed VTE, and in a randomly selected subsample of patients with negative diagnostic workup. Results Of the 8,256 included patients, 96 were pregnant women. A DVT was diagnosed at CUS in 9 women (9.4%). The LEFtscore was computed in all but 7 women with missing values: one point in case of left (‘L’) leg suspicion, one point for edema (‘E’) and one point if the suspicion occurred during the first trimester (‘Ft’) of pregnancy. Prevalence of confirmed DVT was as follows: 1/30 (3%) in women with no LEFt criteria, 3/35 (9%), 2/20 (10%), and 3/4 (75%) in women with 1, 2 and 3 points, respectively. Conclusions Our results confirm the ability of the LEFt rule to estimate the pretest probability of DVT. Future studies are required to prospectively validate these findings and to define the role of the rule in a diagnostic algorithm for DVT during pregnancy. |
| تدمد: | 0049-3848 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519199c15f10011e2d6f2b947ed92153 https://doi.org/10.1016/j.thromres.2014.07.009 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....519199c15f10011e2d6f2b947ed92153 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 00493848 |
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