Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand
| العنوان: | Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand |
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| المؤلفون: | Ren-He Xu, Jaebong Kim, Lisa D. Chong, Teri L Jones, Hsiang-Fu Kung, Ira O. Daar |
| المصدر: | Proceedings of the National Academy of Sciences. 95:576-581 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Mesoderm, Basic fibroblast growth factor, Xenopus, Xenopus Proteins, Ligands, Fibroblast growth factor, Xenopus laevis, chemistry.chemical_compound, Cell Adhesion, medicine, Animals, Receptor, Cell adhesion, Erythropoietin, Membrane Glycoproteins, Multidisciplinary, biology, Erythropoietin - physiology, Erythropoietin-producing hepatocellular (Eph) receptor, Xenopus laevis - embryology - physiology, Biological Sciences, biology.organism_classification, Cell Adhesion - physiology, Molecular biology, Cell biology, medicine.anatomical_structure, Membrane Glycoproteins - physiology, chemistry, Ectopic expression |
| الوصف: | The erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenotype. The carboxyl-terminal 19 amino acids of the cytoplasmic domain of XLerk are necessary but not sufficient to induce cellular dissociation. Basic fibroblast growth factor, but not activin, can rescue both the loss of cell adhesion and mesoderm induction in ectodermal explants expressing XLerk. Collectively, these results show that the cytoplasmic domain of XLerk has a signaling function that is important for cell adhesion, and fibroblast growth factor signaling modulates this function. published_or_final_version |
| وصف الملف: | 384 bytes; text/html |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a46c846e3e5aff9dfc27282fd0bbbc https://doi.org/10.1073/pnas.95.2.576 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....51a46c846e3e5aff9dfc27282fd0bbbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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