Early dorsomedial tissue interactions regulate gyrification of distal neocortex
| العنوان: | Early dorsomedial tissue interactions regulate gyrification of distal neocortex |
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| المؤلفون: | Igor Y. Iskusnykh, Victor V. Chizhikov, Nikolai Fattakhov, Shubha Tole, Achira Roy, Kathleen J. Millen, Ashwin S. Shetty, Ekaterina Y. Steshina, Anne G. Lindgren |
| المصدر: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Nature Communications |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Science, Mesenchyme, LIM-Homeodomain Proteins, Neuroepithelial Cells, General Physics and Astronomy, Lissencephaly, Developmental neurogenesis, Neocortex, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mesoderm, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, lcsh:Science, Gyrification, Mice, Knockout, Regulation of gene expression, Multidisciplinary, Wnt signaling pathway, Neural tube, Cell type diversity, Gene Expression Regulation, Developmental, General Chemistry, medicine.disease, Mice, Inbred C57BL, Wnt Proteins, Neuroepithelial cell, 030104 developmental biology, medicine.anatomical_structure, Female, lcsh:Q, Neuroscience, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors |
| الوصف: | The extent of neocortical gyrification is an important determinant of a species’ cognitive abilities, yet the mechanisms regulating cortical gyrification are poorly understood. We uncover long-range regulation of this process originating at the telencephalic dorsal midline, where levels of secreted Bmps are maintained by factors in both the neuroepithelium and the overlying mesenchyme. In the mouse, the combined loss of transcription factors Lmx1a and Lmx1b, selectively expressed in the midline neuroepithelium and the mesenchyme respectively, causes dorsal midline Bmp signaling to drop at early neural tube stages. This alters the spatial and temporal Wnt signaling profile of the dorsal midline cortical hem, which in turn causes gyrification of the distal neocortex. Our study uncovers early mesenchymal-neuroepithelial interactions that have long-range effects on neocortical gyrification and shows that lissencephaly in mice is actively maintained via redundant genetic regulation of dorsal midline development and signaling. The contribution of long-range signaling to cortical gyrification remains poorly understood. In this study, authors demonstrate that the combined genetic loss of transcription factors Lmx1a and Lmx1b, expressed in the telencephalic dorsal midline neuroepithelium and head mesenchyme, respectively, induces gyrification in the mouse neocortex |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525c0e26c1a722217656ebbd6878efaa https://doi.org/10.1038/s41467-019-12913-z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....525c0e26c1a722217656ebbd6878efaa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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