ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis
| العنوان: | ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis |
|---|---|
| المؤلفون: | James N. Ingle, Vera J. Suman, Vivian Negron, Adam W Nelson, Jordan M. Reese, Igor Chernukhin, Elizabeth S. Bruinsma, Jason S. Carroll, Malayannan Subramaniam, David G. Monroe, Matthew P. Goetz, Ying Li, John R. Hawse |
| المساهمون: | Carroll, Jason [0000-0003-3643-0080], Apollo - University of Cambridge Repository |
| المصدر: | Proceedings of the National Academy of Sciences. 115 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Triple Negative Breast Neoplasms, law.invention, Metastasis, TGFβ, Mice, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Transforming Growth Factor beta, law, In vivo, Cell Line, Tumor, metastasis, Animals, Humans, Medicine, cystatin, Triple-negative breast cancer, Estrogen receptor beta, estrogen receptor beta, Multidisciplinary, business.industry, Tumor Suppressor Proteins, medicine.disease, Cystatins, Phenotype, 030104 developmental biology, PNAS Plus, 030220 oncology & carcinogenesis, Cancer research, Suppressor, Female, Cystatin, business, Signal Transduction |
| الوصف: | Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is associated with improved patient outcomes. We demonstrate that therapeutic activation of ERβ elicits potent anticancer effects in TNBC through the induction of a family of secreted proteins known as the cystatins, which function to inhibit canonical TGFβ signaling and suppress metastatic phenotypes both in vitro and in vivo. These data reveal the involvement of cystatins in suppressing breast cancer progression and highlight the value of ERβ-targeted therapies for the treatment of TNBC patients. |
| وصف الملف: | application/pdf |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b5e1209e5b6d412ef84b87729b7d5c https://doi.org/10.1073/pnas.1807751115 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....52b5e1209e5b6d412ef84b87729b7d5c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
|---|