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In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas

التفاصيل البيبلوغرافية
العنوان: In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas
المؤلفون: H-F, Li, A, Winkeler, S, Moharram, E E, Knaus, K, Dittmar, M, Stöckle, W D, Heiss, L I, Wiebe, A H, Jacobs, A J, Jacob
المصدر: Nucleosides, nucleotidesnucleic acids. 27(1)
سنة النشر: 2008
مصطلحات موضوعية: Male, Gene Expression, Mice, Nude, HSL and HSV, Herpesvirus 1, Human, Pharmacology, medicine.disease_cause, Biochemistry, Thymidine Kinase, Iodine Radioisotopes, chemistry.chemical_compound, Mice, In vivo, Gene expression, Genetics, medicine, Animals, Tissue Distribution, Uridine, Chemistry, Thymidine Kinase Gene, Brain Neoplasms, Arabinofuranosyluracil, Brain, Uracil, General Medicine, Glioma, Molecular biology, Herpes simplex virus, Thymidine kinase, Blood-Brain Barrier, Lipophilicity, Molecular Medicine, Floxuridine
الوصف: Radioiodinated 5-iodo-1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)uracil (F *IAU) is most commonly used for noninvasive assessment of herpes simplex virus type 1 thymidine kinase (HSV-1-tk) gene expression. However, it does not permeate the intact blood-brain barrier (BBB) because of its moderate lipophilicity. In this work, three iodo-nucleosides, FIAU, IVFRU, and IVFAU, were radiolabeled with iodine-123 and tested for permeation of the BBB in mice and for potential measurement of HSV-1-tk gene expression in gliomas. The results demonstrate that brain uptake and retention of these nucleosides is not directly related to their lipophilicity. The low brain uptake of IVFAU, in conjunction with its higher and constant brain/blood ratio, may reflect greater stability against hydrolysis of the N-glycosidic bond. In vivo PET evaluations of [(124)I]IVFRU and [(124)I]IVFAU in tumor-bearing mice are warranted.
تدمد: 1525-7770
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b6010f72254a88d07778eacebb796d
https://pubmed.ncbi.nlm.nih.gov/18188770
رقم الأكسشن: edsair.doi.dedup.....52b6010f72254a88d07778eacebb796d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15257770