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The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

التفاصيل البيبلوغرافية
العنوان: The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience
المؤلفون: Amber Adams, Adam H. Wells, L. Keith Scott, Philip Keith, Stephen H. Fast, Jeremy Hodges
المصدر: Critical Care
Critical Care, Vol 24, Iss 1, Pp 1-10 (2020)
سنة النشر: 2020
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Letter, Multiple Organ Failure, Critical Care and Intensive Care Medicine, MODS, law.invention, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Intensive care, Septic shock, medicine, Humans, APACHE, Aged, Retrospective Studies, APACHE II, Plasma Exchange, business.industry, Research, Organ dysfunction, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, Plasmapheresis, lcsh:RC86-88.9, Water-Electrolyte Balance, Middle Aged, medicine.disease, Shock, Septic, Treatment Outcome, Propensity score matching, SOFA score, Female, medicine.symptom, business
الوصف: Background Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive. Our study aims to evaluate the efficacy of adjunct TPE for septic shock with multiple organ failure compared to standard therapy alone. Methods A retrospective, observational chart review was performed, evaluating outcomes of patients with catecholamine-resistant septic shock and multiple organ failure in intensive care units at a tertiary care hospital in Winston-Salem, NC, from August 2015 to March 2019. Adult patients with catecholamine-resistant septic shock (≥ 2 vasopressors) and evidence of multiple organ failure were included. Patients who received adjunct TPE were identified and compared to patients who received standard care alone. A propensity score using age, gender, chronic co-morbidities (HTN, DM, CKD, COPD), APACHE II score, SOFA score, lactate level, and number of vasopressors was used to match patients, resulting in 40 patients in each arm. Results The mean baseline APACHE II and SOFA scores were 32.5 and 14.3 in TPE patients versus 32.7 and 13.8 in control patients, respectively. The 28-day mortality rate was 40% in the TPE group versus 65% in the standard care group (p = 0.043). Improvements in baseline SOFA scores at 48 h were greater in the TPE group compared to standard care alone (p = 0.001), and patients receiving adjunct TPE had a more favorable fluid balance at 48 h (p = 0.01). Patients receiving adjunct TPE had longer ICU and hospital lengths of stay (p = 0.003 and p = 0.006, respectively). Conclusions Our retrospective, observational study in adult patients with septic shock and multiple organ failure demonstrated improved 28-day survival with adjunct TPE compared to standard care alone. Hemodynamics, organ dysfunction, and fluid balance all improved with adjunct TPE, while lengths of stay were increased in survivors. The study design does not allow for a generalized statement of support for TPE in all cases of sepsis with multiple organ failure but offers valuable information for a prospective, randomized clinical trial.
تدمد: 1466-609X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fa7307375851f02ec83132cc895f7b
https://pubmed.ncbi.nlm.nih.gov/33032656
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....52fa7307375851f02ec83132cc895f7b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1466609X