أعرض في EDS

The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats

التفاصيل البيبلوغرافية
العنوان: The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats
المؤلفون: Adria Giacca, Timothy M. Mason, J Gamble, Ban El-Bahrani, Z. Qing Shi, Tracy Goh, M Prentki, George Steiner, Neehar Gupta, B Chan
المصدر: Atherosclerosis. 161(2)
سنة النشر: 2002
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Injections, Subcutaneous, Adipose tissue, Sensitivity and Specificity, Streptozocin, Diabetes Mellitus, Experimental, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, Medicine, Animals, Insulin, Triglycerides, Probability, chemistry.chemical_classification, Analysis of Variance, biology, Triglyceride, business.industry, Acetyl-CoA carboxylase, Fatty acid, medicine.disease, Streptozotocin, Rats, Fatty acid synthase, Disease Models, Animal, Endocrinology, Glucose, chemistry, Liver, biology.protein, Fatty Acid Synthases, Cardiology and Cardiovascular Medicine, business, Injections, Intraperitoneal, medicine.drug, Acetyl-CoA Carboxylase
الوصف: Chronic intraperitoneal or subcutaneous insulin administration increases triglyceride secretion rate (TGSR) in normal rats. We wished to determine the effect of this treatment on TGSR and the hepatic lipogenic enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) in diabetic rats. Streptozotocin-diabetic rats, untreated (D), diabetic rats treated with insulin (3 U/day for 21 days) intraperitoneally (IP) or subcutaneously (SC) and non-diabetic rats (N) were studied. TGSR was determined using Triton WR-1339. Fasting glucose and triglyceride levels, high in D, were normalized by insulin treatment regardless of route. Peripheral insulin levels were lowest in D and highest in SC, portal insulin levels were lowest in D and highest in IP. Non-esterified fatty acid levels were not elevated in D, presumably due to adipose tissue depletion. TGSR was reduced in D (P
تدمد: 0021-9150
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fedc49e10131600a30b6ce078837e7
https://pubmed.ncbi.nlm.nih.gov/11888517
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....52fedc49e10131600a30b6ce078837e7
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00219150