أعرض في EDS

An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses

التفاصيل البيبلوغرافية
العنوان: An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses
المؤلفون: Yong Zhang, Jinpeng Bi, Jiaye Wang, Fangshen Li, Huaiyu Wang, Bin Yu, Jingcai Lu, Hong Ling, Wei Kong, Feng Gao, Mo Zhang, Xianghui Yu
المصدر: Immunology Letters. 222:29-39
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Mucosal Immune Responses, Guinea Pigs, Immunology, HIV Infections, HIV Antibodies, HIV Envelope Protein gp120, Mucosal vaccine, Mice, 03 medical and health sciences, Immunogenicity, Vaccine, 0302 clinical medicine, Antibody Specificity, Neutralization Tests, medicine, Animals, Humans, Immunology and Allergy, Secretory IgA, Vector (molecular biology), Immunity, Mucosal, AIDS Vaccines, Bacteria, biology, business.industry, Hiv 1 vaccine, env Gene Products, Human Immunodeficiency Virus, virus diseases, biology.organism_classification, Antibodies, Neutralizing, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, HIV-1, Female, Immunization, Nasal administration, business, 030215 immunology, Respiratory tract
الوصف: Although many vaccines have been designed to induce effective mucosal immune responses against HIV-1, designing an effective HIV-1 vaccine remains a challenge. Bacterium-like particles (BLPs) are a new type of vector used to induce mucosal immune responses, and have already been used for some vaccines against respiratory tract viruses. In this study, we designed a mucosal vaccine against HIV-1 based on BLPs. The vaccine was used to immunize both mice and guinea pigs via intramuscular (i.m.) injection or intranasal (i.n.) drip. We found that gp120 trimers bound to BLPs delivered via i.n. drip successfully induced Env-specific secretory IgA (sIgA) at mucosal sites in mice. Furthermore, nasal washes from guinea pigs immunized via i.n. drip showed neutralizing activity against HIV-1 tier 1 pseudoviruses. Thus, gp120 trimers bound to BLPs may be an effective vaccine strategy against HIV-1.
تدمد: 0165-2478
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53546a34ec7661a96638cdfc34232d50
https://doi.org/10.1016/j.imlet.2020.03.002
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....53546a34ec7661a96638cdfc34232d50
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01652478