Biomarkers of Cardiovascular Disease in Patients With Ankylosing Spondylitis
| العنوان: | Biomarkers of Cardiovascular Disease in Patients With Ankylosing Spondylitis |
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| المؤلفون: | Sim Kutlay, Şebnem Ataman, Şehim Kutlay, Ümit Sarp, Evren Üstüner |
| المصدر: | Archives of Rheumatology |
| بيانات النشر: | Turkish League Against Rheumatism, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Applanation tonometry, Ankylosing spondylitis, medicine.medical_specialty, business.industry, pulse wave velocity, Disease, medicine.disease, arterial stiffness, Rheumatology, cardiovascular disease, Internal medicine, medicine, Cardiology, Arterial stiffness, In patient, Functional status, Original Article, business, Pulse wave velocity, Subclinical infection |
| الوصف: | Objectives This study aims to evaluate the inflammatory status and clinical and vascular alterations using tonometry and B-mode sonography in patients with ankylosing spondylitis (AS). Patients and methods The study included 71 AS patients (57 males, 14 females; mean age 40.1±10.8 years; range, 29 to 51 years) without cardiovascular disease and 30 healthy controls (24 males, 6 females; mean age 41.2±9.3 years; range, 32 to 50 years). We evaluated participants' clinical, biological and functional status along with laboratory data and measured both the arterial stiffness using carotid-femoral pulse wave velocity (PWV) measured by applanation tonometry and carotid intima-media thickness (CIMT) as a preclinical atherosclerosis marker. Results The mean disease duration of AS patients was 10.6±4.2 years. CIMT (p=0.03) and PWV (p=0.04) data showed significant differences between AS patients and healthy controls. Multiregression analysis showed that PWV correlated with age (r2=0.42; p=0.03) and disease duration (r2=0.31; p=0.04), while CIMT correlated with disease duration (r2=0.37; p=0.03) and Bath Ankylosing Spondylitis Disease Activity Index (r2=0.3; p=0.04). Conclusion This study demonstrated an increase in early preclinical atherosclerosis in AS patients without cardiovascular (CV) disease compared to healthy controls. Therefore, screening AS patients with noninvasive methods for atherosclerosis and subclinical vasculopathy would allow us to take primary prevention measures. We found that the major determinant for increased CV risk was the disease duration, while there was no difference between different treatment modalities. |
| اللغة: | English |
| تدمد: | 2618-6500 2148-5046 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53587676d8c75676ec258db2a8103db7 http://europepmc.org/articles/PMC7788654 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53587676d8c75676ec258db2a8103db7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26186500 21485046 |
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