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Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile

التفاصيل البيبلوغرافية
العنوان: Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile
المؤلفون: Marilyn L. Kwan, Diana L. Miglioretti, Erin J. A. Bowles, Sheila Weinmann, Robert T. Greenlee, Natasha K. Stout, Alanna Kulchak Rahm, Susan A. Alber, Priscila Pequeno, Lisa M. Moy, Carly Stewart, Cindy Fong, Charisma L. Jenkins, Diane Kohnhorst, Casey Luce, Joanne M. Mor, Julie R. Munneke, Yolanda Prado, Glen Buth, Stephanie Y. Cheng, Kamala A. Deosaransingh, Melanie Francisco, Matthew Lakoma, Yannica Theda Martinez, Mary Kay Theis, Emily C. Marlow, Lawrence H. Kushi, James R. Duncan, Wesley E. Bolch, Jason D. Pole, Rebecca Smith-Bindman
المصدر: Cancer Causes Control
Cancer causes & control : CCC, vol 33, iss 5
بيانات النشر: Springer Science and Business Media LLC, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Ionizing radiation, Retrospective cohort study, Adult, Pediatric Research Initiative, Cancer Research, Adolescent, Pediatric Cancer, Epidemiology, Oncology and Carcinogenesis, Childhood leukemia, Article, Young Adult, Rare Diseases, Clinical Research, Pregnancy, Humans, Conditions Affecting the Embryonic and Fetal Periods, Longitudinal Studies, Aetiology, Child, Computed tomography, Cancer, Retrospective Studies, Pediatric, Ontario, Leukemia, Prevention, Hematology, Health Services, Radiography, Good Health and Well Being, Oncology, Public Health and Health Services, Biomedical Imaging, Female, Medical imaging, Childhood cancer, 2.4 Surveillance and distribution
الوصف: PURPOSE: The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes the study cohorts and research methods. METHODS: The RIC Study is a longitudinal study of children in two retrospective cohorts from 6 U.S. healthcare systems and from Ontario, Canada over the period 1995–2017. The fetal-exposure cohort includes children whose mothers were enrolled in the healthcare system during their entire pregnancy and followed to age 20. The childhood-exposure cohort includes children born into the system and followed while continuously enrolled. Imaging utilization was determined using administrative data. Computed tomography (CT) parameters were collected to estimate individualized patient organ dosimetry. Organ dose libraries for average exposures were constructed for radiography, fluoroscopy, and angiography, while diagnostic radiopharmaceutical biokinetic models were applied to estimate organ doses received in nuclear medicine procedures. Cancers were ascertained from local and state/provincial cancer registry linkages. RESULTS: The fetal-exposure cohort includes 3,474,000 children among whom 6,606 cancers (2,394 leukemias) were diagnosed over 37,659,582 person-years; 0.5% had in utero exposure to CT, 4.0% radiography, 0.5% fluoroscopy, 0.04% angiography, 0.2% nuclear medicine. The childhood-exposure cohort includes 3,724,632 children in whom 6,358 cancers (2,372 leukemias) were diagnosed over 36,190,027 person-years; 5.9% were exposed to CT, 61.1% radiography, 6.0% fluoroscopy, 0.4% angiography, 1.5% nuclear medicine. CONCLUSION: The RIC Study is poised to be the largest study addressing risk of childhood and adolescent cancer associated with ionizing radiation from medical imaging, estimated with individualized patient organ dosimetry.
وصف الملف: application/pdf
تدمد: 1573-7225
0957-5243
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5384d11bd7505c01f7cbdd12d2a3f037
https://doi.org/10.1007/s10552-022-01556-z
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....5384d11bd7505c01f7cbdd12d2a3f037
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15737225
09575243