Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
| العنوان: | Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development |
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| المؤلفون: | Sabrina, Paganoni, James D, Berry, Melanie, Quintana, Eric, Macklin, Benjamin R, Saville, Michelle A, Detry, Marianne, Chase, Alexander V, Sherman, Hong, Yu, Kristin, Drake, Jinsy, Andrews, Jeremy, Shefner, Lori B, Chibnik, Matteo, Vestrucci, Merit E, Cudkowicz, Margherita, Torti |
| المصدر: | Annals of Neurology. 91:165-175 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Clinical Trials as Topic, Neurology, Endpoint Determination, Research Design, Amyotrophic Lateral Sclerosis, Animals, Humans, Neurology (clinical), Biomarkers |
| الوصف: | Current therapeutic development in amyotrophic lateral sclerosis (ALS) relies on individual randomized clinical trials to test a specific investigational product in a single patient population. This approach has intrinsic limitations, including cost, time, and lack of flexibility. Adaptive platform trials represent a novel approach to investigate several interventions for a single disease in a continuous manner. Already in use in oncology, this approach is now being employed more often in neurology. Here, we describe a newly launched platform trial for ALS. The Healey ALS Platform Trial is testing multiple investigational products concurrently in people with ALS, with the goal of rapidly identifying novel treatments, biomarkers, and trial endpoints. ANN NEUROL 2022;91:165-175. |
| تدمد: | 1531-8249 0364-5134 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53991fcbeb0b07905e37fb08161b3a4e https://doi.org/10.1002/ana.26285 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53991fcbeb0b07905e37fb08161b3a4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318249 03645134 |
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