Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus
| العنوان: | Distinct interferon response in bat and other mammalian cell lines infected with Pteropine orthoreovirus |
|---|---|
| المؤلفون: | Eiichi Hondo, Ronald Tarigan, Tetsufumi Katta, Atsuo Iida, Ken Maeda, Hitoshi Takemae, Hiroshi Shimoda |
| المصدر: | Virus Genes |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Swine, animal diseases, viruses, Pattern recognition receptor, Porcine Reproductive and Respiratory Syndrome, Antiviral Agents, Cell Line, Interferon, Chiroptera, Virology, Genetics, medicine, Animals, Molecular Biology, Original Paper, Innate immune system, biology, Rhinolophus ferrumequinum, Bat, virus diseases, MDA5, General Medicine, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Orthoreovirus, Viral replication, Cell culture, Receptors, Pattern Recognition, TLR3, Interferons, Pteropine orthoreovirus, medicine.drug |
| الوصف: | Bats serve as natural hosts of Pteropine orthoreovirus (PRV), an emerging group of bat-borne, zoonotic viruses. Bats appear to possess unique innate immune system responses that can inhibit viral replication, thus reducing clinical symptoms. We examined the innate immune response against PRV and assessed viral replication in cell lines derived from four bat species (Miniopterus fuliginosus, Pteropus dasymallus, Rhinolophus ferrumequinum, and Rousettus leschenaultii), one rodent (Mesocricetous auratus), and human (Homo sapiens). The expression levels of pattern recognition receptors (PRRs) (TLR3, RIG-I, and MDA5) and interferons (IFNB1 and IFNL1) were higher and PRV replication was lower in cell lines derived from M. fuliginosus, R. ferrumequinum, and R. leschenaultii. Reduction of IFNB1 expression by the knockdown of PRRs in the cell line derived from R. ferrumequinum was associated with increased PRV replication. The knockdown of RIG-I led to the most significant reduction in viral replication for all cell lines. These results suggest that RIG-I production is important for antiviral response against PRV in R. ferrumequinum. Supplementary Information The online version contains supplementary material available at 10.1007/s11262-021-01865-6. |
| تدمد: | 1572-994X 0920-8569 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a9f15033448d7cffc4c00aaf027eef https://doi.org/10.1007/s11262-021-01865-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53a9f15033448d7cffc4c00aaf027eef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1572994X 09208569 |
|---|