Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes
| العنوان: | Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes |
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| المؤلفون: | Yujia Mo, Shouying Du, Qi Zhang, Jie Bai, Wan-Wan Tian, Yu-Tao Xue, Yahua Cui |
| المصدر: | Molecules Volume 23 Issue 12 Molecules, Vol 23, Iss 12, p 3371 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Materials science, Physical approach, Dispersity, Pharmaceutical Science, Paeoniflorin, 02 engineering and technology, Paeonia, 030226 pharmacology & pharmacy, Article, Analytical Chemistry, lcsh:QD241-441, microneedle, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Glucosides, ethosomes, Drug Discovery, Zeta potential, Particle Size, Physical and Theoretical Chemistry, Transdermal, Organic Chemistry, Penetration (firestop), 021001 nanoscience & nanotechnology, total glucosides of paeony, Bioavailability, chemistry, Chemistry (miscellaneous), transdermal, Monoterpenes, Molecular Medicine, Particle size, 0210 nano-technology, Biomedical engineering |
| الوصف: | Paeoniflorin, the main component of total glucosides of paeony (TGP), shows good therapeutic effects in arthritis, but has low bioavailability when administered orally. Avoiding such a deficiency for topical administration would expand its clinical application. This study aimed to avoid these limitations by using nanotechnology (ethosomes) and a physical approach (microneedles). Paeoniflorin-loaded ethosomal formulation (TGP-E) was optimized and evaluated in terms of entrapment efficiency (EE), particle size (PS), zeta potential (ZP), polydispersity index (PDI) and morphology. TGP-E was prepared by the hot injection method and optimized by single-factor tests and an orthogonal experimental design. The optimized paeoniflorin-loaded ethosomes had EE of 27.82 ± 1.56%, PS of 137.9 ± 7.57 nm with PDI of 0.120 ± 0.005, ZP of &minus 0.74 ± 0.43 mV. Ethosomes showed a nearly spherical shape under the transmission electron microscope (TEM). The optimal microneedle-assisted (MN-assisted) conditions were obtained at a microneedle length of 500 &mu m, a pressure of 3 N and an action time of 3 min. The cumulative penetration amounts (Qn) of TGP solution transdermal (ST) and MN-assisted TGP solution transdermal (MST) were 24.42 ± 8.35 &mu g/cm2 and 548.11 ± 10.49 &mu g/cm2, respectively. Qn of TGP-E transdermal (PT) and MN-assisted TGP-E transdermal (MPT) were 54.97 ± 4.72 &mu g/cm2 and 307.17 ± 26.36 &mu g/cm2, respectively. These findings indicate that use of ethosomes and microneedles can both enhance the penetration ofpaeoniflorin, but for the water-soluble drug, there is no obvious synergism between nanotechnology and microneedles for enhancing penetration in a transdermal drug delivery system. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b2a3208200bfefa3e85e61725c30f1 https://doi.org/10.3390/molecules23123371 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53b2a3208200bfefa3e85e61725c30f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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