Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium
| العنوان: | Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium |
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| المؤلفون: | John B. Finlay, David H. Brann, Ralph Abi Hachem, David W. Jang, Allison D. Oliva, Tiffany Ko, Rupali Gupta, Sebastian A. Wellford, E. Ashley Moseman, Sophie S. Jang, Carol H. Yan, Hiroaki Matsunami, Tatsuya Tsukahara, Sandeep Robert Datta, Bradley J. Goldstein |
| المصدر: | Science translational medicine, vol 14, iss 676 Sci Transl Med |
| بيانات النشر: | eScholarship, University of California, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Anosmia, Gene Expression, Medical and Health Sciences, Article, Vaccine Related, Olfaction Disorders, Rare Diseases, Olfactory Mucosa, Clinical Research, Biodefense, Animals, Humans, 2.1 Biological and endogenous factors, Viral, Aetiology, Lung, SARS-CoV-2, Prevention, Neurosciences, COVID-19, General Medicine, Biological Sciences, Emerging Infectious Diseases, Good Health and Well Being, RNA, Viral, RNA |
| الوصف: | SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how SARS-CoV-2 causes persistent smell loss in a subset of patients. To address this question, we analyzed olfactory epithelial samples collected from 24 biopsies, including from nine patients with objectively quantified long-term smell loss after COVID-19. This biopsy-based approach revealed a diffuse infiltrate of T cells expressing interferon-γ and a shift in myeloid cell population composition, including enrichment of CD207 + dendritic cells and depletion of anti-inflammatory M2 macrophages. Despite the absence of detectable SARS-CoV-2 RNA or protein, gene expression in the barrier supporting cells of the olfactory epithelium, termed sustentacular cells, appeared to reflect a response to ongoing inflammatory signaling, which was accompanied by a reduction in the number of olfactory sensory neurons relative to olfactory epithelial sustentacular cells. These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cfa0014ecbd61505dcdd10bf5c1689 https://escholarship.org/uc/item/7w67866s |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53cfa0014ecbd61505dcdd10bf5c1689 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |