Synthesis and Anticonvulsant Activity of SomeN-Phenyl-2-phtalimidoethanesulfonamide Derivatives
| العنوان: | Synthesis and Anticonvulsant Activity of SomeN-Phenyl-2-phtalimidoethanesulfonamide Derivatives |
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| المؤلفون: | Ozlem Akgul, Fatma Sultan Kilic, Kevser Erol, Varol Pabuccuoglu |
| المصدر: | Archiv der Pharmazie. 340:656-660 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Electroshock, Sulfonamides, Magnetic Resonance Spectroscopy, Stereochemistry, Chemistry, medicine.medical_treatment, Pharmaceutical Science, Phthalimides, Dose level, Ring (chemistry), Mice, Structure-Activity Relationship, Taltrimide, Anticonvulsant, Seizures, Drug Discovery, Nitro, medicine, Animals, Pentylenetetrazole, Moiety, Molecule, Anticonvulsants, Pharmacophore |
| الوصف: | In this study, inspired by the structures of the taltrimide, 2-phthalimidoethanesulphonamide, and the anilide pharmacophore known to be synthetically produced anticonvulsant compounds, fifteen N-phenyl-2-phtalimidoethanesulfonamide derivatives bearing substituents with diverse electronic and hydrophobic features on N-phenyl ring were synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure in mice at a dose level of 100 mg/kg. The preliminary screening results indicated that the exchange of the N-isopropyl moiety for an N-phenyl ring in the taltrimide molecule abolished the anticonvulsant activity. However, introducing certain substituents, such as nitro, methyl, and chloro, into the N-phenyl ring lead to more active compounds in comparison to the unsubstituted derivatives. |
| تدمد: | 1521-4184 0365-6233 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ddbe70eaa5747c29680f88f858f9c7 https://doi.org/10.1002/ardp.200700166 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....53ddbe70eaa5747c29680f88f858f9c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214184 03656233 |
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