Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability
| العنوان: | Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability |
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| المؤلفون: | Fabrice Girardot, Céline Vivien, Louise Péricard, Karima Palmier, Pierluigi Scerbo, Laurent Coen, Lindsey Marshall, Barbara A. Demeneix |
| المساهمون: | Evolution des régulations endocriniennes (ERE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Murdoch Children's Research Institute (MCRI), Signalisation normale et pathologique de l'embryon aux thérapies innovantes des cancers, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Universite Paris-Saclay, 91198 ´ Gif-sur-Yvette, France, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Girardot, Fabrice |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (9), pp.3614-3623. ⟨10.1073/pnas.1803794116⟩ Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (9), pp.3614-3623. ⟨10.1073/pnas.1803794116⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0303 health sciences, Multidisciplinary, biology, Regeneration (biology), media_common.quotation_subject, Thyroid, Xenopus, biology.organism_classification, medicine.disease, Regenerative process, Cell biology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Heart failure, [SDV.BDD] Life Sciences [q-bio]/Development Biology, medicine, Metamorphosis, Zebrafish, [SDV.BDD]Life Sciences [q-bio]/Development Biology, 030217 neurology & neurosurgery, 030304 developmental biology, Hormone, media_common |
| الوصف: | International audience; Despite therapeutic advances, heart failure is the major cause of morbidity and mortality worldwide, but why cardiac regenerative capacity is lost in adult humans remains an enigma. Cardiac regenerative capacity widely varies across vertebrates. Zebrafish and newt hearts regenerate throughout life. In mice, this ability is lost in the first postnatal week, a period physiologically similar to thyroid hormone (TH)-regulated metamorphosis in anuran amphibians. We thus assessed heart regeneration in Xenopus laevis before, during, and after TH-dependent metamorphosis. We found that tadpoles display efficient cardiac regeneration, but this capacity is abrogated during the metamorphic larval-to-adult switch. Therefore, we examined the consequence of TH excess and deprivation on the efficiently regenerating tadpole heart. We found that either acute TH treatment or blocking TH production before resection significantly but differentially altered gene expression and kinetics of extracellular matrix components deposition, and negatively impacted myocardial wall closure, both resulting in an impeded regenerative process. However, neither treatment significantly influenced DNA synthesis or mitosis in cardiac tissue after amputation. Overall, our data highlight an unexplored role of TH availability in modulating the cardiac regenerative outcome, and present X. laevis as an alternative model to decipher the developmental switches underlying stage-dependent constraint on cardiac regeneration. |
| اللغة: | English |
| تدمد: | 0027-8424 1091-6490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e0c25f3f86c62836be6e4bae6285ca https://hal.archives-ouvertes.fr/hal-03319960 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....53e0c25f3f86c62836be6e4bae6285ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 10916490 |
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