MicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11)
| العنوان: | MicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11) |
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| المؤلفون: | Huayi Ren, Sha Li, Hailin Zhang, Ying Liu, Xiao Zhou, Zan Li, Mingjing Peng, Yazhou Xiao, Jie Dai, Ying Long, Anji Xu, Chenhui Luo, Liang Yi |
| المصدر: | Bioengineered article-version (VoR) Version of Record Bioengineered, Vol 12, Iss 1, Pp 5830-5838 (2021) |
| بيانات النشر: | Taylor & Francis, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Untranslated region, Cell cycle checkpoint, proliferation, Bioengineering, tongue squamous cell carcinoma, medicine.disease_cause, Applied Microbiology and Biotechnology, Tongue, Cell Line, Tumor, microRNA, medicine, Humans, Luciferase, Cell Proliferation, Cell growth, Chemistry, Squamous Cell Carcinoma of Head and Neck, Proteins, General Medicine, Transfection, prr11, Cell cycle, Prognosis, Tongue Neoplasms, Mir-26b-5p, MicroRNAs, Cancer research, cell cycle, Carcinogenesis, TP248.13-248.65, Biotechnology, Research Article, Research Paper |
| الوصف: | MicroRNAs (miRNAs) have been proved to be involved in many biological processes during tumorigenesis and progression, including cell proliferation and cell cycle progression. However, the potential role of miR-26b-5p in tongue squamous cell carcinoma (TSCC) remains unclear. In the present study, we demonstrated that miR-26b-5p was decreased in TSCC tissues in both TCGA-TSCC subset and eight paired samples from TSCC patients, while Proline Rich 11 (PRR11) was obviously increased. Transfection of miR-26b-5p mimics inhibited CALL7 cell proliferation by arresting the cells at the S/G2 transition. Meanwhile, miR-26b-5p inhibitor had the opposite biological functions. The results of luciferase activity and RNA-pulldown assays indicated that miR-26b-5p directly targeted the PRR11 3ʹ -untranslated region in CAL27 cells. Furthermore, the effects of miR-26b-5p on cell cycle regulation were reversed after treatment with siRNA against PRR11. In summary, our findings indicate that miR-26b-5p induce cell cycle arrest in TSCC by targeting PRR11. Hence, targeting miR-26b-5p could be a promising therapeutic strategy for the treatment of TSCC. |
| اللغة: | English |
| تدمد: | 2165-5987 2165-5979 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543df396c32eb53ec1b5b03c2553ed5d http://europepmc.org/articles/PMC8806564 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....543df396c32eb53ec1b5b03c2553ed5d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 21655987 21655979 |
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