Association of estrogen receptor α gene PvuII and XbaI polymorphisms with non-small cell lung cancer
| العنوان: | Association of estrogen receptor α gene PvuII and XbaI polymorphisms with non-small cell lung cancer |
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| المؤلفون: | Chung-Kuang Su, Shyng-Shiou F. Yuan, Chi-Chiang Yang, Ming Chih Chou, Fu-Gong Lin, Fu‑Hsin Chang, Li-Feng Liu, Huai-Lu Chang, Yu-Jen Cheng, Meng-Chih Chen, Chien-Fu Huang |
| المصدر: | Oncology Letters. 3:462-468 |
| بيانات النشر: | Spandidos Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Genetics, Cancer Research, education.field_of_study, Linkage disequilibrium, Population, Haplotype, Single-nucleotide polymorphism, Articles, Biology, medicine.disease, Genotype frequency, Oncology, Genotype, medicine, Lung cancer, XX Genotype, education |
| الوصف: | Single nucleotide polymorphisms (SNPs) of the estrogen receptor (ER)-α have been found to be associated with various diseases at significantly different frequencies. However, whether any relationship exists between ER-α polymorphisms and lung cancer remains to be determined. In this study, 84 non-smoking, female, non-small cell lung cancer patients with various stages of disease and 234 cancer-free reference controls were enrolled to examine the association of ER-α polymorphisms in lung cancer. Two restriction SNP sites, PvuII and XbaI, in the first intron of the ER-α gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism. The frequencies of the PvuII-XbaI haplotypes and genotypes in a Taiwanese population were revealed for the first time. Although the genotypic frequencies of two polymorphic sites of ER- α were in linkage disequilibrium for the lung cancer group (χ(2)=50.013, d.f.=4) and reference controls (χ(2)=60.797, d.f.=4); and 7 and 8 combined genotypes were present, respectively, the distribution and the major genotypes are different in the two groups (p |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5469c9237efbf72cbb13135715e16a0e https://doi.org/10.3892/ol.2011.482 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5469c9237efbf72cbb13135715e16a0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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