Mitochondria‐derived damage‐associated molecular patterns and inflammation in the ischemic‐reperfused heart
| العنوان: | Mitochondria‐derived damage‐associated molecular patterns and inflammation in the ischemic‐reperfused heart |
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| المؤلفون: | May‐Kristin Torp, Jarle Vaage, Kåre‐Olav Stensløkken |
| المصدر: | Acta Physiologica. 237 |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology |
| الوصف: | Cardiac cell death after myocardial infarction release endogenous structures termed damage associated molecular patterns (DAMPs) that trigger the innate immune system and initiate a sterile inflammation in the myocardium. Cardiomyocytes are energy demanding cells and 30% of their volume are mitochondria. Mitochondria are evolutionary endosymbionts originating from bacteria containing molecular patterns similar to bacteria, termed mitochondrial DAMPs (mDAMPs). Consequently, mitochondrial debris may be particularly immunogenic and damaging. However, the role of mDAMPs in myocardial infarction is not clarified. Identifying the most harmful mDAMPs and inhibiting their early inflammatory signaling may reduce infarct size and the risk of developing post-infarct heart failure. The focus of this review is the role of mDAMPs in the immediate pro-inflammatory phase after myocardial infarction before arrival of immune cells in the myocardium. We discuss different mDAMPs, their role in physiology and present knowledge regarding their role in the inflammatory response of acute myocardial infarction. |
| تدمد: | 1748-1716 1748-1708 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547e3f39e3cc3c92d64fb5709dc0710b https://doi.org/10.1111/apha.13920 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....547e3f39e3cc3c92d64fb5709dc0710b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17481716 17481708 |
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