Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy
| العنوان: | Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy |
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| المؤلفون: | Wenge Li, Yue Yang, Shi-min Jiang, Hongmei Gao, Zheng Zhang, Pei-lin Dai, Ye-ping Ma, Yi-ning Wang, Gu-ming Zou |
| المصدر: | Molecular and Cellular Biochemistry. 453:103-110 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Angiotensin receptor, Clinical Biochemistry, Peptidyl-Dipeptidase A, urologic and male genital diseases, Proto-Oncogene Mas, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Nephropathy, Renin-Angiotensin System, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Renin–angiotensin system, medicine, Humans, Receptor, Molecular Biology, Proteinuria, medicine.diagnostic_test, business.industry, Glomerulonephritis, IGA, Cell Biology, General Medicine, Middle Aged, medicine.disease, Angiotensin II, female genital diseases and pregnancy complications, Glomerular Mesangium, 030104 developmental biology, Endocrinology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Female, Renal biopsy, medicine.symptom, business, Kidney disease |
| الوصف: | The critical role of the intrarenal renin-angiotensin system (RAS) in the development of kidney disease has been well demonstrated in animal and cell-culture experiments, but evidence from human kidney tissues is lacking. In this study, we screened 438 patients with IgA nephropathy (IgAN) and analyzed their clinical characteristics. Renal biopsy revealed the expression of angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and MAS receptor (MASR) in the tissues of 260 patients not treated with RAS inhibitors, 32 patients treated with angiotensin-converting enzyme inhibitors (ACEIs), and 89 patients treated with angiotensin receptor blockers (ARBs). The correlations in expression among these three receptors and the results of Oxford typing were analyzed, together with the ability of ACEIs and ARBs to reduce proteinuria and the effects of ARBs on AT1R and AT2R expression. The results showed significantly higher AT1R, AT2R, and MASR expression in the M1 group (mesangial score 0.5) than in the M0 group (mesangial score 0.5), significantly higher AT1R expression in the S1 group (presence of segmental glomerulosclerosis) than in the S0 group (absence of segmental glomerulosclerosis); AT1R expression in the C2 group (crescent formation 25%) was significantly higher than in the C0 (crescent formation = 0) and C1 (crescent formation 25%) groups. Patients treated with an ARB for 6 months had significantly lower urinary protein levels than those taking these drugs for 6 months. These findings imply that overexpression of AT1R on the mesangial cells of IgAN patients is associated with mesangial cell proliferation, glomerular segmental sclerosis, and crescent formation. In addition, long-term administration of ARB may decrease the efficacy of these medications in terms of reducing proteinuria. |
| تدمد: | 1573-4919 0300-8177 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b199831331f068491c6d8d6ae7a6da https://doi.org/10.1007/s11010-018-3435-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....54b199831331f068491c6d8d6ae7a6da |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15734919 03008177 |
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