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Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32)

التفاصيل البيبلوغرافية
العنوان: Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32)
المؤلفون: Roger G. Owen, Stephen Morris, Helen Dickinson, Rumana Rashid, Jarek Czyz, Sheila J.M. O’Connor, Roderick J. Johnson
المصدر: Cancer Genetics and Cytogenetics. 171:101-104
بيانات النشر: Elsevier BV, 2006.
سنة النشر: 2006
مصطلحات موضوعية: Cancer Research, Lymphoma, B-Cell, Chromosomal translocation, Biology, Translocation, Genetic, Polyploidy, Cyclin D1, hemic and lymphatic diseases, Tumor Cells, Cultured, Genetics, medicine, Humans, Molecular Biology, Chromosomes, Human, Pair 14, Intravascular large B-cell lymphoma, medicine.diagnostic_test, Chromosomes, Human, Pair 11, Karyotype, Middle Aged, BCL6, medicine.disease, Molecular biology, Vascular Neoplasms, Lymphoma, DNA-Binding Proteins, Karyotyping, Proto-Oncogene Proteins c-bcl-6, Female, Interphase, Lymphoma, Large B-Cell, Diffuse, Fluorescence in situ hybridization
الوصف: Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/cyclin D1 dual-color, dual-fusion probe set and cyclin D1 immunohistochemical analysis. Abnormality of 3q was also evident. Interphase FISH analysis with a dual-color, break-apart probe set confirmed rearrangement of BCL6. To our knowledge, this is the first report of these abnormalities in IVL.
تدمد: 0165-4608
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fc77a253fbb924c0b9d08fd81cec36
https://doi.org/10.1016/j.cancergencyto.2006.07.018
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....54fc77a253fbb924c0b9d08fd81cec36
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01654608