Antigen receptor repertoire profiling from RNA-seq data
| العنوان: | Antigen receptor repertoire profiling from RNA-seq data |
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| المؤلفون: | Dmitriy M. Chudakov, Lorenzo F. Fanchi, Olga Zolotareva, Anna S. Obraztsova, Dmitriy A. Bolotin, Felix Frenkel, Ton N. Schumacher, Alexey N. Davydov, Alexander Y. Rudensky, Ataullakhanov Ravshan I, S. V. Poslavsky, Saskia Hemmers, Mikhail Shugay, Ekaterina V. Putintseva |
| المصدر: | Nature Biotechnology. 35:908-911 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Receptors, Antigen, T-Cell, Biomedical Engineering, Bioengineering, RNA-Seq, Computational biology, Biology, Applied Microbiology and Biotechnology, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, Immune system, Antibody Repertoire, Databases, Genetic, Animals, Humans, Somatic recombination, Melanoma, Sequence Analysis, RNA, Gene Expression Profiling, T-cell receptor, Computational Biology, High-Throughput Nucleotide Sequencing, RNA, Acquired immune system, Receptors, Antigen, 030104 developmental biology, chemistry, Molecular Medicine, Algorithms, DNA, Biotechnology |
| الوصف: | Somatic recombination and accumulation of mutations in V-D-J segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1,2. High-throughput profiling of immune receptors has become an important tool for studies of adaptive immunity and for the development of diagnostics, vaccines, and immunotherapies3,4,5,6,7. There are efficient molecular and software tools for the targeted sequencing of TCR and immunoglobulin repertoires6,8, including MiXCR, developed by our team9. However, sufficient amount and quality of tissue or extracted RNA or DNA are not always available for analysis. |
| تدمد: | 1546-1696 1087-0156 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554c7d64cd84291e35d47f5869df6a53 https://doi.org/10.1038/nbt.3979 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....554c7d64cd84291e35d47f5869df6a53 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461696 10870156 |
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