A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation
| العنوان: | A new original nutraceutical formulation ameliorates the effect of Tadalafil on clinical score and cGMP accumulation |
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| المؤلفون: | Raffaella Sorrentino, Roberto La Rocca, Roberta d'Emmanuele di Villa Bianca, Vincenzo Mirone, Giuseppe Celentano, Arianna Vanelli, Emma Mitidieri, Davide Arcaniolo, Domenico Vanacore, Carlotta Turnaturi, Giuseppe Cirino, Luigi Napolitano |
| المساهمون: | Mirone, V., Napolitano, L., Bianca, R. D. D. V., Mitidieri, E., Sorrentino, R., Vanelli, A., Vanacore, D., Turnaturi, C., Rocca, R. L., Celentano, G., Arcaniolo, D., Cirino, G., d'Emmanuele di Villa Bianca, R. |
| المصدر: | Archivio Italiano di Urologia e Andrologia, Vol 93, Iss 2 (2021) |
| بيانات النشر: | PAGEPress Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Urology, 030232 urology & nephrology, Physical examination, Phosphodiesterase: natural health product, Placebo, Natural health product, Gastroenterology, Group B, Tadalafil, Moringa, Dietary supplement, 03 medical and health sciences, Ginseng, 0302 clinical medicine, Nutraceutical, Internal medicine, medicine, Humans, Blood test, Phosphodiesterase, Erectile dysfunction, Aged, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, business.industry, Penile Erection, Middle Aged, Diseases of the genitourinary system. Urology, Treatment Outcome, Dietary Supplements, RC870-923, Pde5, business, Human, medicine.drug |
| الوصف: | Objective: To assess the efficacy of the combination of Tadalafil 5 mg and nutritional supplements composed by Panax ginseng, Moringa Oleifera and Rutin on erectile function in men with mild and moderate vasculogenic ED.Methods: we prospectively enrolled 86 patients divided into two groups A (45), B (33) in this multicenter randomized, doubleblind, placebo-controlled trial . Drop out was 8 patients (3 patients in group A and 5 in Group B). At screening visit patients underwent clinical examination, blood test (hormonal and metabolic profile) and filled out the IIEF-5 questionnaire and the SEP-2, SEP-3. Patients were randomized by a computergenerated list to receive either Tadalafil 5 mg once daily plus nutritional supplement once daily (group A) or Tadalafil 5 mg plus placebo with the same administration schedule (group B) for 3 months. Blood samples, IIEF-5, SEP-2 and SEP-3 have been collected again after 3 months. cGMP was measured in platelets of 38 patients at baseline and after one months. Results: Mean age was 59.98 ± 6.90 (range 38-69), mean IIEF-5 score at baseline was 13.59 ± 3.90. After three months of treatment, IIEF-5 score significantly improved in both groups compared to baseline (13.18 ± 3.75 vs 20.48 ± 2.24, p < 0.0001; 14.15 ± 4.09 vs 19.06 ± 4.36, p < 0.0001, in group A and group B respectively). Patients treated with Tadalafil plus nutritional supplement showed a significantly higher increase in IIEF-5 score compared to those who received placebo (7.27 ± 2.20 and 4.9 ± 2.79, respectively; p < 0.0001;). No hormonal differences and metabolic effects were found. According cGMP result, nutritional supplements ameliorates and extends the activity of the chronic treatment. Conclusions: IIEF-5 significant increase in group B, can be ascribed to the nutritional supplement properties and antioxidant effects of moringa oleifera, ginseng and rutin and this can enhance the endothelial NO and cGMP production. |
| تدمد: | 2282-4197 1124-3562 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5550ba750b35f6fdbaecb6e2b52191a5 https://doi.org/10.4081/aiua.2021.2.221 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5550ba750b35f6fdbaecb6e2b52191a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22824197 11243562 |
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