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Development of bone seeker radiopharmaceuticals by Scandium-47 and estimation of human absorbed dose

التفاصيل البيبلوغرافية
العنوان: Development of bone seeker radiopharmaceuticals by Scandium-47 and estimation of human absorbed dose
المؤلفون: Leila Moghaddam-Banaem, Leila Deilami-nezhad, Mahdi Sadeghi
المصدر: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 129
سنة النشر: 2016
مصطلحات موضوعية: Biodistribution, Bone seeker, chemistry.chemical_element, Ethylenediamine, Bone Neoplasms, In Vitro Techniques, 010403 inorganic & nuclear chemistry, Ligands, Radiation Dosage, 01 natural sciences, Bone and Bones, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Organophosphorus Compounds, Drug Stability, Organometallic Compounds, Dosimetry, Animals, Humans, Tissue Distribution, Scandium, Radioisotopes, EDTMP, Radiation, Radiochemistry, Etidronic Acid, 0104 chemical sciences, chemistry, Absorbed dose, Radiopharmaceuticals
الوصف: In this study labeling EDTMP (ethylenediamine tetra(methylene phosphonic acid)) and HEDP (Hydroxyethylidene-1, 1-Diphosphonic Acid) as the carrier ligands with Scandium-47 were investigated. The biokinetics of the bone seeking of labeled ligands with Scandium-47 were assessed by measuring the skeletal absorbed dose and then the mice data extrapolated to human absorbed dose and compared with the 186/188Rhenium-HEDP, 153Samarium-EDTMP dosimetry data estimated by other researchers. Because the availability of 47Sc was limited we performed some preliminary studies using 46Sc.
تدمد: 1872-9800
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559b028ce613f5d5940887cf2461aee2
https://pubmed.ncbi.nlm.nih.gov/28843158
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....559b028ce613f5d5940887cf2461aee2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18729800