التفاصيل البيبلوغرافية
| العنوان: |
Data from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion |
| المؤلفون: |
Montse Sanchez-Cespedes, Suvi Savola, Elisabeth Brambilla, Luca Roz, Alberto Villanueva, David Sidransky, Agustin Vidal, Enric Condom, Julian Carretero, Juan Pablo Rodrigo, Maria Dolores Chiara, Sylvie Lantuejoul, Federica Facchinetti, Ilse Zondervan, Sara Verdura, Ester Bonastre |
| بيانات النشر: |
American Association for Cancer Research (AACR), 2023. |
| سنة النشر: |
2023 |
| الوصف: |
Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung squamous cell carcinomas (LSCC). Tumor-specific PARD3 alterations were found in 8% of LSCCs examined, placing PARD3 among the most common tumor suppressor genes in this malignancy. Most PAR3-mutant proteins exhibited a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions, bind atypical protein kinase C, activate RAC1, and activate STAT3 at cell confluence. Thus, PARD3 alterations prevented the formation of contacts between neighboring cells and the subsequent downstream signaling. Notably, reconstituting PAR3 activity in vivo reduced tumor-invasive and metastatic properties. Our findings define PARD3 as a recurrently inactivated cell polarity regulator in LSCC that affects tumor aggressiveness and metastasis. Cancer Res; 75(7); 1287–97. ©2015 AACR. |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559b2be3367982241a60c0ba6305cf36
https://doi.org/10.1158/0008-5472.c.6507201.v1 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....559b2be3367982241a60c0ba6305cf36 |
| قاعدة البيانات: |
OpenAIRE |
