Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs
| العنوان: | Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs |
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| المؤلفون: | Eric Li, Stuart W. Paine, Sally Colgan, Steven Karamatic, Paul Zahra, T. H. Morris |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics. 42:505-510 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Flunixin, Urinary system, Urine, Pharmacology, Drug levels, Excretion, Dogs, Pharmacokinetics, Blood plasma, medicine, Animals, Infusions, Intravenous, General Veterinary, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Hydrogen-Ion Concentration, Drug Residues, Clonixin, Area Under Curve, Plasma concentration, Female, business, Half-Life, Sports, medicine.drug |
| الوصف: | © 2019 John Wiley & Sons Ltd Medication control in greyhound racing requires information from administration studies that measure drug levels in the urine as well as plasma, with time points that extend into the terminal phase of excretion. To characterize the plasma and the urinary pharmacokinetics of flunixin and enable regulatory advice for greyhound racing in respect of both medication and residue control limits, flunixin meglumine was administered intravenously on one occasion to six different greyhounds at the label dose of 1mg/kg and the levels of flunixin were measured in plasma for up to 96hr and in urine for up to 120hr. Using the standard methodology for medication control, the irrelevant plasma concentration was determined as 1ng/ml and the irrelevant urine concentration was determined as 30ng/ml. This information can be used by regulators to determine a screening limit, detection time and a residue limit. The greyhounds with the highest average urine pH had far greater flunixin exposure compared with the greyhounds that had the lowest. This is entirely consistent with the extent of ionization predicted by the Henderson–Hasselbalch equation. This variability in the urine pharmacokinetics reduces with time, and at 72hr postadministration, in the terminal phase, the variability in urine and plasma flunixin concentrations are similar and should not affect medication control. |
| وصف الملف: | |
| تدمد: | 1365-2885 0140-7783 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c21285e2e77b716a7b376bd4e0f46b https://doi.org/10.1111/jvp.12775 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....55c21285e2e77b716a7b376bd4e0f46b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652885 01407783 |
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