Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice
| العنوان: | Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice |
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| المؤلفون: | Kazutaka Hirabayashi, Xian Xian, Akira Imai, Megumu Tanaka, Akiko Kamiyoshi, Nanqi Cui, Takayuki Sakurai, Kyoko Igarashi, Keiya Tanimura, Tian Liu, Kun Dai, Akihiro Yamauchi, Hisaka Kawate, Yuka Ichikawa-Shindo, Takayuki Shindo, Liuyu Zhai, Lei Yang, Teng Liu |
| المصدر: | Endocrinology. 158:1194-1206 |
| بيانات النشر: | The Endocrine Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Adipose Tissue, White, Calcitonin Gene-Related Peptide, Adipose tissue, White adipose tissue, Calcitonin gene-related peptide, Diet, High-Fat, Energy homeostasis, Cardiovascular Physiological Phenomena, Mice, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Animals, Homeostasis, Calcitonin receptor, Mice, Knockout, integumentary system, Adiponectin, Chemistry, Leptin, Body Weight, Lipid Metabolism, Up-Regulation, Mice, Inbred C57BL, Glucose, 030104 developmental biology, nervous system, Calcitonin, Energy Metabolism, 030217 neurology & neurosurgery |
| الوصف: | Calcitonin gene-related peptide (CGRP) is a bioactive peptide produced by alternative splicing of the primary transcript of the calcitonin/CGRP gene. CGRP is largely distributed in the cardiovascular and nervous systems, where it acts as a regulatory factor. CGRP is also expressed in organs and tissues involved in metabolic regulation, including white adipose tissue (WAT), where its function is largely unknown. In this study, we examined the effects of endogenous CGRP on metabolic function. When we administered a high-fat diet to CGRP-specific knockout (CGRP-/-) and wild-type (WT) mice for 10 weeks, we observed that food intake did not differ between the two groups, but body weight and visceral fat weight were significantly lower in CGRP-/- mice. Fatty liver changes were less severe in CGRP-/- mice, which also showed lower serum insulin and leptin levels. Glucose tolerance and insulin sensitivity were better in CGRP-/- than WT mice, and expired gas analysis revealed greater oxygen consumption by CGRP-/- mice. Adipocyte hypertrophy was suppressed in CGRP-/- mice, while expression of β-3-adrenergic receptor, hormone-sensitive lipase and adiponectin was enhanced. Isoproterenol-induced glycerol release from WAT was higher in CGRP-/- than WT mice, and CGRP-/- mice showed elevated sympathetic nervous activity. β-receptor-blockade canceled the beneficial effects of CGRP deletion on obesity. These results suggest that, in addition to its actions in the cardiovascular system, endogenous CGRP is a key regulator of metabolism and energy homeostasis in vivo. |
| تدمد: | 1945-7170 0013-7227 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604747b23efcfc0ede607edda878d7c https://doi.org/10.1210/en.2016-1510 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5604747b23efcfc0ede607edda878d7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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