A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy
| العنوان: | A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy |
|---|---|
| المؤلفون: | Min-Zhe Wang, Hong Wu, Zhe Yu, Tiehong Yang, Xin He |
| المصدر: | Molecules, Vol 25, Iss 3096, p 3096 (2020) Molecules Volume 25 Issue 13 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Angelica sinensis, medicine.medical_treatment, Pharmaceutical Science, 02 engineering and technology, Pharmacology, doxorubicin, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Immune system, lcsh:Organic chemistry, Drug Discovery, medicine, Doxorubicin, Physical and Theoretical Chemistry, 030304 developmental biology, 0303 health sciences, Chemotherapy, Tumor microenvironment, synergistic therapy, biology, Chemistry, Organic Chemistry, Cancer, Immunotherapy, Angelica sinensis polysaccharide, 021001 nanoscience & nanotechnology, medicine.disease, biology.organism_classification, enzymes sensitive drug delivery, Chemistry (miscellaneous), Drug delivery, Molecular Medicine, 0210 nano-technology, medicine.drug |
| الوصف: | Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive tumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide) was constructed. In this system, Angelica polysaccharides act as not only carriers to targeted delivery of drugs to tumor tissue but also effectors to improve tumor microenvironment and enhance immune function, resulting in synergistic antitumor effect with chemotherapy drugs. The structure of this conjugate was confirmed by FI-IR and 1H-NMR. The particle size and zeta potential of the nanoparticles were 129.00 ± 3.32 nm and &minus 28.45 ± 0.22 mV, respectively. Doxorubicin (DOX) and AP could be quickly released from the AP-PP-DOX under the presence of matrix metalloproteinase 2 (MMP2). The released DOX showed good antitumor efficacy in vitro. The treatment of released AP moiety increased the expression of IL-2, while that of IL-10 was decreased, showing potential in restoring Th1/Th2 immune balance in tumor microenvironment. In a word, this drug delivery system, with specific tissue targeting and tumor microenvironment improvement, will open a new avenue for combination treatment of cancer. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56128bf301c7beb1ef1e285af5ba902a https://www.mdpi.com/1420-3049/25/13/3096 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....56128bf301c7beb1ef1e285af5ba902a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
|---|