Early onset of neurological features differentiates two outbreaks of Lassa fever in Ebonyi state, Nigeria during 2017-2018
| العنوان: | Early onset of neurological features differentiates two outbreaks of Lassa fever in Ebonyi state, Nigeria during 2017-2018 |
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| المؤلفون: | Emeka Sampson, Christina Psarra, Obumneme Ezeanosike, RC Onoh, Jacques K. Tshiang, Nnennaya Anthony Ajayi, Rebecca Harrison, Ugochukwu Uzodimma Nnadozie, Jacob Maikere, Chiedozie K. Ojide, Uchenna Anebonam, Emeka O. Onwe, Anthony Reid, Uche S. Unigwe, Collins Nwachi Ugwu, Julita Gil-Cuesta, Azuka Stephen Adeke, Damian U. Nwidi, Nneka M. Chika-Igwenyi, Maria Gulamhusein |
| المصدر: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009169 (2021) |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Rural Population, Pediatrics, Viral Diseases, Urban Population, Epidemiology, RC955-962, Artificial Gene Amplification and Extension, Disease, medicine.disease_cause, Polymerase Chain Reaction, Disease Outbreaks, Geographical Locations, 0302 clinical medicine, Medical Conditions, Arctic medicine. Tropical medicine, Case fatality rate, Medicine and Health Sciences, Public and Occupational Health, 030212 general & internal medicine, Lassa fever, Neck Pain, Reverse Transcriptase Polymerase Chain Reaction, Mortality rate, Middle Aged, Clinical Laboratory Sciences, Clinical Laboratories, Infectious Diseases, Consciousness Disorders, Female, Public aspects of medicine, RA1-1270, Research Article, Neglected Tropical Diseases, Adult, medicine.medical_specialty, Death Rates, 030231 tropical medicine, Nigeria, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Lassa Fever, Population Metrics, Diagnostic Medicine, Seizures, Virology, medicine, Humans, Molecular Biology Techniques, Hearing Loss, Lassa virus, Molecular Biology, Retrospective Studies, Population Biology, business.industry, Public health, Public Health, Environmental and Occupational Health, Outbreak, Biology and Life Sciences, Reverse Transcriptase-Polymerase Chain Reaction, medicine.disease, Tropical Diseases, People and Places, Africa, business |
| الوصف: | Lassa fever (LF) is an acute viral haemorrhagic illness with various non-specific clinical manifestations. Neurological symptoms are rare at the early stage of the disease, but may be seen in late stages, in severely ill patients.The aim of this study was to describe the epidemiological evolution, socio-demographic profiles, clinical characteristics, and outcomes of patients seen during two Lassa fever outbreaks in Ebonyi State, between December 2017 and December 2018. Routinely collected clinical data from all patients admitted to the Virology Centre of the hospital during the period were analysed retrospectively. Out of a total of 83 cases, 70(84.3%) were RT-PCR confirmed while 13 (15.7%) were probable cases. Sixty-nine (83.1%) patients were seen in outbreak 1 of whom 53.6% were urban residents, while 19%, 15%, and 10% were farmers, students and health workers respectively. There were 14 (16.8%) patients, seen in second outbreak with 92.9% rural residents. There were differences in clinical symptoms, signs and laboratory findings between the two outbreaks. The case fatality rates were 29.9% in outbreak 1 and 85.7% for outbreak 2. Neurological features and abnormal laboratory test results were associated with higher mortality rate, seen in outbreak 2. This study revealed significant differences between the two outbreaks. Of particular concern was the higher case fatality during the outbreak 2 which may be from a more virulent strain of the Lassa virus. This has important public health implications and further molecular studies are needed to better define its characteristics. Author summary Neurological manifestations are uncommon in the early stages of Lassa Fever. In Ebonyi State, an unusual pattern was observed between two outbreaks that occurred quite close together in time but with distinctly different presentations. Previous studies on the 2018 outbreak focused on the first part of the outbreak between December 2017—May 2018. We therefore compared the two outbreaks and observed that patients in the second outbreak which occurred between August 2018-December 2018, presented with early neurological symptoms and a high mortality rate. This observation highlights the need for further evaluation and molecular studies. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564240bc27b44ff7b513e0bb724fb101 http://hdl.handle.net/10144/619913 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....564240bc27b44ff7b513e0bb724fb101 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |