The utility of three-dimensional computed tomography for prediction of tumor invasiveness in clinical stage IA lung adenocarcinoma
| العنوان: | The utility of three-dimensional computed tomography for prediction of tumor invasiveness in clinical stage IA lung adenocarcinoma |
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| المؤلفون: | Masayuki Nakao, Yasuto Kondo, Junji Ichinose, Hiroki Ozawa, Yosuke Matsuura, Yohei Kawaguchi, Mingyon Mun, Sakae Okumura, Naoya Iwamoto, Kenshiro Omura |
| المصدر: | J Thorac Dis |
| بيانات النشر: | AME Publishing Company, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung, medicine.diagnostic_test, Relative efficacy, business.industry, Irregular shape, Computed tomography, 030204 cardiovascular system & hematology, medicine.disease, Stage IA Lung Adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Statistical significance, medicine, Adenocarcinoma, Original Article, Radiology, Stage (cooking), business |
| الوصف: | Background It is critical to have an accurate measurement of solid tumor size in order to predict the invasiveness of small lung adenocarcinomas. Some lesions cannot be measured accurately via High-resolution computed tomography (HRCT) due to their irregular shape and unclear borders. For this reason, we evaluated the relative efficacy of three-dimensional (3D) CT for predicting invasive adenocarcinoma. Methods We evaluated 195 patients with clinical stage IA adenocarcinomas, including 109 with lesions documented as invasive that were surgically resected at our institute during 2017. All lesions were categorized as either (I) lesions that were difficult to evaluate (i.e., hazy lesions; HL) or (II) more typical lesions (TL). The relationships between solid tumor size as determined by HRCT, solid tumor volume as determined by 3D CT and pathologic diagnosis were evaluated. Results Fifty-seven patients (29%) were diagnosed with HL. We set the cut-off value for the solid volume at 225 mm3 as predictive for invasive adenocarcinoma. When evaluating all 195 patients as a group, the accuracy, sensitivity, and specificity based on the solid tumor volume were similar to those based on the solid tumor size. When we limit our analysis to the HL group, the specificity based on solid tumor volume (65.5%) was higher than that based on solid tumor size (44.8%) with a difference that approached statistical significance (P=0.070). Conclusions 3D CT was equivalent to HRCT for predicting invasive adenocarcinoma and may be particularly useful for diagnosing lesions that are difficult to evaluate on HRCT. |
| تدمد: | 2077-6624 2072-1439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c5f9b57fd836f9d45576f01f886391 https://doi.org/10.21037/jtd-20-2131 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....56c5f9b57fd836f9d45576f01f886391 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20776624 20721439 |
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