Overview of HIV treatment failure in Africa using the WHO Pharmacovigilance data
| العنوان: | Overview of HIV treatment failure in Africa using the WHO Pharmacovigilance data |
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| المؤلفون: | Joe Miantezila Basilua, Philippe Pochart, Gauthier Mesia Kahunu, Gaston Tona Lutete |
| المصدر: | Tropical Medicine & International Health. 26:530-534 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Adolescent, Databases, Factual, MedDRA, 030231 tropical medicine, Population, HIV Infections, Drug resistance, World Health Organization, Pharmacovigilance, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Treatment Failure, Hiv treatment, Child, education, Retrospective Studies, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Infant, Odds ratio, Confidence interval, Infectious Diseases, Anti-Retroviral Agents, Child, Preschool, Africa, Female, Parasitology, Observational study, business, Demography |
| الوصف: | Objective To characterize the factors associated with HIV treatment failure (HIVTF) from reported pharmacovigilance data in Africa. Materials and methods This is an observational pharmacovigilance analysis of the safety data of HIVTF available in the WHO International Pharmacovigilance database "VigiBase®". We used the Standardized MedDRA Queries (SMQ) to identify all the terms corresponding to HIVTF. To identify all relevant molecules and classes of antiretroviral therapy, we used the Anatomic, Therapeutic, and Chemical classification. We presented results as a percentage or an adjusted Reporting Odds Ratio (aROR) with a 95% confidence interval (95% CI). Results HIVTF was more reported in Africa compared to the rest of the world with 19.1% (18.1% - 20.1%) corresponding to 1206 of all 6304 HIVTF reports. Among all the 37 WHO country members in Africa, South Africa was the main source of origin for these HIVTF reports with 86.8% (84.9% - 88.7%). Compared to adults, children and adolescents were the most population groups affected by HIVTF, aROR = 2.7, (95% CI) 1.7 - 4.2 and aROR = 7.9, (95% CI) 4.5 - 13.9, respectively. Conclusion South Africa was the leading country of the reporting of HIVTF in Africa. The proportion of HIVTF was higher in both HIV-infected children and adolescents than in adults. There is a need for the improvement of medical care for children and adolescents with HIV infection in Africa. |
| تدمد: | 1365-3156 1360-2276 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e17e8e0661c02ab94033dbaed8289e https://doi.org/10.1111/tmi.13556 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....56e17e8e0661c02ab94033dbaed8289e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13653156 13602276 |
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