HIV viral load trajectories of women living with HIV in Metro Vancouver, Canada
| العنوان: | HIV viral load trajectories of women living with HIV in Metro Vancouver, Canada |
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| المؤلفون: | Mary Kestler, Ruth Elwood Martin, Melissa Braschel, Flo Ranville, Putu Duff, Kate Shannon, Andrea Krüsi, Kathleen N. Deering |
| المصدر: | Int J STD AIDS |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Canada, Younger age, Human immunodeficiency virus (HIV), HIV Infections, Dermatology, 030312 virology, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Antiretroviral Therapy, Highly Active, Humans, Medicine, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Hiv treatment, Prospective cohort study, Reproductive health, 0303 health sciences, business.industry, Public Health, Environmental and Occupational Health, Odds ratio, Middle Aged, Viral Load, medicine.disease, CD4 Lymphocyte Count, 3. Good health, Infectious Diseases, Female, business, Viral load, Demography |
| الوصف: | This study describes long-term viral load (VL) trajectories and their predictors among women living with HIV (WLWH), using data from Sexual Health and HIV/AIDS: Women’s Longitudinal Needs Assessment (SHAWNA), an open prospective cohort study with linkages to the HIV/AIDS Drug Treatment Program. Using Latent Class Growth Analysis (LCGA) on a sample of 153 WLWH (1088 observations), three distinct trajectories of detectable VL (≥50 copies/ml) were identified: ‘sustained low probability of detectable VL’, characterized by high probability of long-term VL undetectability (51% of participants); ‘ high probability of delayed viral undetectability’, characterized by a high probability VL detectability at baseline that decreases over time (43% of participants); and ‘ high probability of detectable VL’, characterized by a high probability of long-term VL detectability (7% of participants). In multivariable analysis, incarceration (adjusted odds ratio (AOR) = 3.24; 95%CI:1.34–7.82), younger age (AOR = 0.96; 95%CI:0.92–1.00), and lower CD4 count (AOR = 0.82; 95%CI:0.72–0.93) were associated with ‘ high probability of delayed viral undetectability’ compared to ‘sustained low probability of detectable VL.’ This study reveals the dynamic and heterogeneous nature of WLWH’s long-term VL patterns, and highlights the need for early engagement in HIV care among young WLWH and programs to mitigate the destabilizing impact of incarceration on WLWH’s HIV treatment outcomes. |
| تدمد: | 1758-1052 0956-4624 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa7291a5fe6c8d2854c3a67354781a https://doi.org/10.1177/0956462420965847 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....56fa7291a5fe6c8d2854c3a67354781a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581052 09564624 |
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