Havula, E [0000-0002-9253-5816], Lamichane, N [0000-0002-1746-0332], Francis, D [0000-0002-4158-1521], Liu, Y [0000-0002-6419-1980], Alton, LA [0000-0002-4236-2494], Johnstone, J [0000-0002-8523-9269], Needham, EJ [0000-0001-6326-9048], Jiwnani, N [0000-0001-7308-7109], Audia, G [0000-0002-8957-2536], Alves, AN [0000-0002-1650-8058], Sylow, L [0000-0003-0905-5932], Mirth, C [0000-0002-9765-4021], Neely, GG [0000-0002-1957-9732], Yang, J [0000-0002-5271-2603], Hietakangas, V [0000-0002-9900-7549], Simpson, SJ [0000-0003-0256-7687], Senior, AM [0000-0001-9805-7280], Apollo - University of Cambridge Repository, Centre of Excellence in Stem Cell Metabolism, Molecular and Integrative Biosciences Research Programme, University of Helsinki, Nutrient sensing laboratory, Institute of Biotechnology, Biosciences
المصدر:
Havula, E, Ghazanfar, S, Lamichane, N, Francis, D, Hasygar, K, Liu, Y, Alton, L A, Johnstone, J, Needham, E J, Pulpitel, T, Clark, T, Niranjan, H N, Shang, V, Tong, V, Jiwnani, N, Audia, G, Alves, A N, Sylow, L, Mirth, C, Neely, G G, Yang, J, Hietakangas, V, Simpson, S J & Senior, A M 2022, ' Genetic variation of macronutrient tolerance in Drosophila melanogaster ', Nature Communications, vol. 13, 1637 . https://doi.org/10.1038/s41467-022-29183-x
بيانات النشر:
Apollo - University of Cambridge Repository, 2022.
Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a “dietary generalist”, displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
