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Efficient enzymatic synthesis of the sialyl-LewisX tetrasaccharide A ligand for selectin-type adhesion molecules

التفاصيل البيبلوغرافية
العنوان: Efficient enzymatic synthesis of the sialyl-LewisX tetrasaccharide A ligand for selectin-type adhesion molecules
المؤلفون: Roger O'Neill, Theodora de Vries, Dirk H. van den Eijnden, Jody Schultz
المصدر: FEBS Letters. (3):243-248
بيانات النشر: Published by Elsevier B.V.
مصطلحات موضوعية: Stereochemistry, Molecular Sequence Data, Biophysics, Lewis X Antigen, Oligosaccharides, Biochemistry, Structural Biology, αl→3-Fucosyltransferase, Cell Adhesion, Genetics, Humans, Tetrasaccharide, Selectin, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, Chemistry, Cell adhesion molecule, Amino Sugars, Cell Biology, Adhesion, Enzymatic synthesis, Fucosyltransferases, Ligand (biochemistry), α2→3-Sialyltransferase, Sialyltransferases, carbohydrates (lipids), Enzyme, Carbohydrate Sequence, Yield (chemistry), E-Selectin, Cell Adhesion Molecules, Sialyl-Lex
الوصف: Sialyl-Lewisx (NeuAc alpha 2--3Gal beta 1--4[Fuc alpha 1--3]GlcNAc] has been identified as a ligand for E-selectin, P-selectin and recently also for L-selectin. We have synthesized the sialyl-Lewisx tetrasaccharide by total enzymatic synthesis from N-acetyllactosamine using a placental alpha 2--3-sialyltransferase specific for type-2 chain acceptors, followed by a cloned human alpha 1--3-fucosyltransferase (FucTV, the 'plasma-type' enzyme). This procedure resulted in the tetrasaccharide in a 61% overall yield.
اللغة: English
تدمد: 0014-5793
DOI: 10.1016/0014-5793(93)80881-T
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571eed5ce3f28e1b439c2705fec3f4f2
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....571eed5ce3f28e1b439c2705fec3f4f2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00145793
DOI:10.1016/0014-5793(93)80881-T