Clustered repetitive transcranial magnetic stimulation for the prevention of depressive relapse/recurrence: a randomized controlled trial
| العنوان: | Clustered repetitive transcranial magnetic stimulation for the prevention of depressive relapse/recurrence: a randomized controlled trial |
|---|---|
| المؤلفون: | Zhong-Heng Wang, Zhang-Jin Zhang, L. Guo, Huaning Wang, Jun-chang Liu, Xiao-Xia Wang, Yu-Ting Qiao, Ying Wang, Qingrong Tan, Yu-Chen Wan, Run-zhu Sun, Ya-Hong Zhang, Rui-Guo Zhang, Min Cai, Hong He |
| المصدر: | Translational Psychiatry, Vol 7, Iss 12, Pp 1-9 (2017) Translational Psychiatry |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Combination therapy, medicine.medical_treatment, Brief Communication, behavioral disciplines and activities, lcsh:RC321-571, law.invention, Young Adult, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Randomized controlled trial, Recurrence, law, Internal medicine, mental disorders, Secondary Prevention, Humans, Combined Modality Therapy, Medicine, Young adult, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, Depressive Disorder, Major, business.industry, Relapse/recurrence, Hazard ratio, Middle Aged, Transcranial Magnetic Stimulation, Antidepressive Agents, 030227 psychiatry, Transcranial magnetic stimulation, Psychiatry and Mental health, Treatment Outcome, nervous system, Antidepressant, Female, business, 030217 neurology & neurosurgery |
| الوصف: | Repetitive transcranial magnetic stimulation (rTMS) may have the potential to prevent depressive relapse. This assessor-blinded, randomized controlled study was designed to evaluate the efficacy and safety of rTMS as a mono- and combination therapy in the prevention of depressive relapse/recurrence. A total of 281 depressed patients who had achieved stable full or partial remission on a 6-month antidepressant (ADP) run-in treatment were randomly assigned to an rTMS (n = 91), ADP (n = 108), or combined (rTMS + ADP, n = 82) treatment group for 12 months. Monthly clustered rTMS was conducted in 5–10 sessions over a 3–5-day period. Maintenance outcomes were assessed using time to relapse/recurrence and relapse/recurrence rate. Overall, 71.2% (200/281) of the participants completed the treatment per the protocol. rTMS + ADP and rTMS significantly reduced the risk of relapse/recurrence compared with ADP (P = 0.000), with hazard ratios of 0.297 and 0.466, respectively. Both rTMS-containing regimens produced significantly lower relapse/recurrence rates than ADP (15.9% and 24.2% vs. 44.4%, P |
| تدمد: | 2158-3188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573e9ae89e12d4b6fc25383b9e9d950d https://doi.org/10.1038/s41398-017-0001-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....573e9ae89e12d4b6fc25383b9e9d950d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 |
|---|