Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
| العنوان: | Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles |
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| المؤلفون: | Pamela Basto, Lindsey Dean, Christopher Cannizzaro, Robert Langer, Rohit Karnik, William Kyei-Manu, Omid C. Farokhzad, Frank X. Gu |
| المصدر: | Nano Letters. 8:2906-2912 |
| بيانات النشر: | American Chemical Society (ACS), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Materials science, Polymers, Mechanical Engineering, Microfluidics, Dispersity, Nanoparticle, Bioengineering, Nanotechnology, General Chemistry, Polymer, Condensed Matter Physics, chemistry.chemical_compound, chemistry, Drug delivery, Chemical Precipitation, Nanoparticles, Nanomedicine, General Materials Science, Particle Size, Drug carrier, Ethylene glycol |
| الوصف: | A central challenge in the development of drug-encapsulated polymeric nanoparticles is the inability to control the mixing processes required for their synthesis resulting in variable nanoparticle physicochemical properties. Nanoparticles may be developed by mixing and nanoprecipitation of polymers and drugs dissolved in organic solvents with nonsolvents. We used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery. We demonstrate that by varying (1) flow rates, (2) polymer composition, and (3) polymer concentration we can optimize the size, improve polydispersity, and control drug loading and release of the resulting nanoparticles. This work suggests that microfluidics may find applications for the development and optimization of polymeric nanoparticles in the newly emerging field of nanomedicine. |
| تدمد: | 1530-6992 1530-6984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a78bb29f272456e6862583ee8057c0 https://doi.org/10.1021/nl801736q |
| رقم الأكسشن: | edsair.doi.dedup.....57a78bb29f272456e6862583ee8057c0 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15306992 15306984 |
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