Vascular calcification and atherosclerosis in hemodialysis patients: what can we learn from the routine clinical practice?

التفاصيل البيبلوغرافية
العنوان: Vascular calcification and atherosclerosis in hemodialysis patients: what can we learn from the routine clinical practice?
المؤلفون: Zoran Trajkovski, Vili Amitov, Aleksandar Sikole, Goge Damjanovski, Sonja Dzikova, Saso Gelev, Goce Spasovski
المصدر: International urology and nephrology. 40(3)
سنة النشر: 2007
مصطلحات موضوعية: Vitamin, Nephrology, Adult, Male, medicine.medical_specialty, Urology, Radiography, medicine.medical_treatment, Population, Gastroenterology, Bone remodeling, chemistry.chemical_compound, Renal Dialysis, Risk Factors, Internal medicine, medicine, Humans, Vascular Diseases, education, Aged, Ultrasonography, Aged, 80 and over, education.field_of_study, Analysis of Variance, Chi-Square Distribution, business.industry, Calcinosis, Middle Aged, medicine.disease, Atherosclerosis, Arterial calcification, Cross-Sectional Studies, chemistry, Cardiology, Kidney Failure, Chronic, Female, Hemodialysis, business, Kidney disease
الوصف: Hemodialysis (HD) patients are at increased risk for arterial intimal (AIC) and medial calcification (AMC). In a cross-sectional study on 153 HD patients we evaluated the presence of AIC and AMC using plain radiography of the pelvis and the presence of atherosclerotic lesions using high-resolution B-mode ultrasonography of the common carotid arteries (CCA). The radiography of the pelvis confirmed the frequent presence of AIC (35.3%) and AMC (35.9%) in our HD patients. Arterial calcification was absent (non calcified—NC) in a minority of patients (28.8%). Patients with AIC had significantly higher prevalence of atherosclerotic plaques on CCA (78.6%) compared with both other groups and a higher number of documented atherosclerotic complications, such as cardiovascular (85.2%), cerebrovascular (33.3%) and peripheral arterial disease (38.9%) in comparison with the NC patients. According to the 1-year calculated data from patient records, there were no significant differences in the specific HD risks, such as the dose of prescribed calcium carbonate and vitamin D3, serum levels of calcium, phosphate, calcium-phosphate product and intact parathyroid hormone. All four bone metabolism markers within the range proposed by K/DOQI guidelines were achieved in 9.3%, 14.5% and 20.4% in the AIC, AMC and NC group, respectively. Patients with AIC and AMC are frequently found in the HD population. Screening for arterial calcifications in chronic kidney disease patients is suggested even in the early pre-dialysis period. The highest proportion of patients within the guidelines proposed range for bone and mineral metabolism markers was observed in the NC group. A longer period of data analysis is required in order to evaluate the possible role of some traditional and HD-specific risk factors for the development of arterial calcifications. The achievement of the K/DOQI guidelines is an important issue in the prevention of those conditions.
تدمد: 0301-1623
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c908345420e644db2e861c9f75c706
https://pubmed.ncbi.nlm.nih.gov/18584302
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....57c908345420e644db2e861c9f75c706
قاعدة البيانات: OpenAIRE